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Merck
모든 사진(1)

주요 문서

SML2948

Sigma-Aldrich

Mca-APK(Dnp)-OH trifluoroacetate

≥97% (HPLC)

동의어(들):

Mca-APK(Dnp) TFA salt (Mca = 7-Methoxycoumarin-4-yl; Dnp = 2,4-dinitrophenyl), Mca-Ala-Pro-Lys(Dnp) TFA salt, Mca-Ala-Pro-Lys(Dnp)-OH TFA salt

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C32H36N6O12 · xC2HF3O2
Molecular Weight:
696.66 (free base basis)
UNSPSC 코드:
12352200
NACRES:
NA.77

Quality Level

100

분석

≥97% (HPLC)

양식

film or powder

저장 조건

desiccated

색상

white to dark beige

저장 온도

−20°C

생화학적/생리학적 작용

Mca-APK(Dnp)-OH is a widely used fluorescent substrate for angiotensin-converting enzyme 2 (ACE2 cleaves between P & K). Proteolytic cleavage separates 7-methoxycoumarin-4-acetyl (Mca) from the fluorescence-quenching group 2,4-dinitrophenyl (Dnp), resulting in increased Mca fluorescence (Ex: 320-328 nm, Em: 405-420 nm). The fluorescence increase over background upon Mca-APK(Dnp) cleavage is more than 14-fold higher than that of Mca-YVADAPK(Dnp), while only Mca-YVADAPK(Dnp), but not Mca-APK(Dnp), can also be used for assessing caspase-1 (ICE) activity.
Popular fluorescent substrate for angiotensin-converting enzyme 2 (ACE2).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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Journal of cellular physiology, 234(12), 22809-22818 (2019-05-28)
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