SML2944

Mca-YVADAPK(Dnp)-OH trifluoroacetate

≥97% (HPLC)

• 동의어(들): Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp), TFA salt, Mca-Tyr-Val-Ala-Asp-Ala-Pro-Lys(Dnp)-OH, TFA salt, Mca-YVADAPK(Dnp), TFA salt (Mca = 7-Methoxycoumarin-4-yl; Dnp = 2,4-dinitrophenyl)
• 실험식(Hill 표기법): C₅₃H₆₄N₁₀O₁₉ · xC₂HF₃O₂
• Molecular Weight: 1145.13 (free base basis)
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥97% (HPLC)
• 양식: film or powder
• 색상: white to dark beige
• 저장 온도: −20°C

설명

생화학적/생리학적 작용

Mca-YVADAPK(Dnp)-OH is a widely used fluorescent substrate for caspase-1 (ICE cleaves between D & A) and angiotensin-converting enzyme 2 (ACE2 cleaves between P & K). Proteolytic cleavage separates 7-methoxycoumarin-4-acetyl (Mca) from the fluorescence-quenching group 2,4-dinitrophenyl (Dnp), resulting in increased Mca fluorescence (Ex: 320-328 nm, Em: 405-420 nm).

Popular fluorescent substrate for caspase-1 (ICE) and angiotensin-converting enzyme 2 (ACE2).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable