SBR00079

Delamanid

≥98% (HPLC), powder

• Synonyme(s) : OPC-67683
• Formule empirique (notation de Hill) : C₂₅H₂₅F₃N₄O₆
• Numéro CAS: 681492-22-8
• Poids moléculaire : 534.48
• Code UNSPSC : 51101500

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: dry media
• Couleur: white to off-white
• Spectre d'activité de l'antibiotique: mycobacteria
• Mode d’action: cell wall synthesis | inhibits
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: C[C@@]1(CN2C=C(N=C2O1)[N+](=O)[O-])COC3=CC=C(C=C3)N4CCC(CC4)OC5=CC=C(C=C5)OC(F)(F)F
• InChI: InChI=1S/C25H25F3N4O6/c1-24(15-31-14-22(32(33)34)29-23(31)38-24)16-35-18-4-2-17(3-5-18)30-12-10-20(11-13-30)36-19-6-8-21(9-7-19)37-25(26,27)28/h2-9,14,20H,10-13,15-16H2,1H3/t24-/m1/s1
• Clé InChI: XDAOLTSRNUSPPH-XMMPIXPASA-N

Description

Description générale

Delamanid is an anti-tuberculosis agent derived from the nitro-dihydro-imidazooxazole class of compounds that inhibits mycolic acid synthesis of bacterial cell wall. A limitation of dasabuvir is the lower potential for cross-genotypic activity as the binding sites are poorly preserved across HCV genotypes.

Actions biochimiques/physiologiques

Delamanid is an antimycobacterial agent that inhibits mycolic acid synthesis, an essential component of the cell wall of Mycobacterium tuberculosis. Inhibition of mycolic acid synthesis leads to the disruption of cell wall structure and integrity, and ultimately, bacterial cell death.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H361d
• Conseils de prudence: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classification des risques: Repr. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable