SBR00060

Bedaquiline Fumarate

≥97% (HPLC), powder

• Synonyme(s) : Baloxin
• Formule linéaire : C₃₂H₃₁BrN₂O₂·C₄H₄O₄
• Numéro CAS: 845533-86-0
• Code UNSPSC : 51101500

Propriétés

• Niveau de qualité: 100
• Essai: ≥97% (HPLC)
• Forme: powder
• Couleur: white to off-white
• Spectre d'activité de l'antibiotique: mycobacteria
• Mode d’action: enzyme | inhibits
• Chaîne SMILES: CN(C)CC[C@@](C1=CC=CC2=CC=CC=C21)([C@H](C3=CC=CC=C3)C4=C(N=C5C=CC(=CC5=C4)Br)OC)O.C(=C/C(=O)O)\C(=O)O
• InChI: 1S/C32H31BrN2O2.C4H4O4/c1-35(2)19-18-32(36,28-15-9-13-22-10-7-8-14-26(22)28)30(23-11-5-4-6-12-23)27-21-24-20-25(33)16-17-29(24)34-31(27)37-3;5-3(6)1-2-4(7)8/h4-17,20-21,30,36H,18-19H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t30-,32-;/m1./s1
• Clé InChI: ZLVSPMRFRHMMOY-WWCCMVHESA-N

Description

Description générale

Bedaquiline fumarate is an antibioitc with antimycobacterial properties. Bedaquiline fumarate a fumarate salt prepared from equimolar amounts of bedaquiline and fumaric acid. It has a role as an antitubercular agent and an ATP synthase inhibitor.

Application

Bedaquiline Fumarate has also been studied for its potential use in bioluminescence imaging, due to its ability to bind to a reporter protein and enhance its luminescence signal. This has potential applications in a variety of biological research areas, such as protein-protein interactions, drug discovery, and disease modeling.

Actions biochimiques/physiologiques

Bedaquiline Fumarate is an antimycobacterial agent that inhibits mycobacterial ATP synthase, an enzyme essential for energy metabolism in Mycobacterium tuberculosis. Inhibition of ATP synthase disrupts the energy production of the bacteria and leads to their death. Bedaquiline Fumarate is active against mycobacteria.

Informations sur la sécurité

• Pictogrammes: GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H410
• Conseils de prudence: P273 - P391 - P501
• Classification des risques: Aquatic Chronic 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable