SML3310

DN02

≥98% (HPLC)

• 동의어(들): 4-(4-((3-Aminoazetidin-1-yl)methyl)-2,6-dimethoxyphenyl)-7-fluoro-2-methylisoquinolin-1(2H)-one
• 실험식(Hill 표기법): C₂₂H₂₄FN₃O₃
• Molecular Weight: 397.44
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: -10 to -25°C

설명

생화학적/생리학적 작용

DN02 is a potent and selective BRD8 first bromodomain inhibitor (BRD8(1) IC50 = 48 nM, BRD4(1) & BRD9 IC50 ≥10 μM; Kd = 34 nM/BRD8(1), >1 μM/BRD8(2), CBP, p300) that serves as a useful chemical probe for the selective engagement of BRD8 and enrichment of native NuA4 complexes.

Potent and selective BRD8 first bromodomain inhibitor for probing the engagement of BRD8 and enrichment of native NuA4 complexes.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3