SML3850

I-BET432

≥98% (HPLC)

• 동의어(들): (R)-7-((R)-1,2-Dihydroxyethyl)-1,3-dimethyl-5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]azepin-2(3H)-one, GSK 3740432, GSK-3740432, GSK3740432
• 실험식(Hill 표기법): C₁₈H₂₁N₃O₃
• Molecular Weight: 327.38
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: -10 to -25°C

설명

생화학적/생리학적 작용

I-BET432 is a bromodomain (BrD) inhibitor with selectivity toward the BET family of bromodomain-containing proteins (BrD1/2 pKd = 8.3/8.1 (BRD2), 8.5/8.1 (BRD3), 8.3/8.2 (BRD4), 8.3/7.8 (BRDT) by DiscoRx BROMOscan) with little or no affinity toward bromodomain-containng proteins (BCPs) and BrDs, including CREBBP, TRIM24, EP300, WDR9 BD2, PBRM1 BD2, TAF1 BD2, BAZ2A (pKd <5.9 from DiscoRx BROMOscan panel). I-BET432 inhibits LPS-stimulated MCP-1 production from human white blood cells (pIC50 = 7.4) with oral availability and good in vivo pharmacokinetic properties.

Orally available bromodomain (BrD) inhibitor with selectivity toward the BET family of bromodomain-containing proteins BRD2/3/4 and BRDT.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable