SML2968

JA2131

≥98% (HPLC)

• 동의어(들): 1,3,6,9-Tetrahydro-1,3-dimethyl-8-[[2-(4-morpholinyl)ethyl]thio]-6-thioxo-2H-purin-2-one, NSC 98003, NSC98003
• 실험식(Hill 표기법): C₁₃H₁₉N₅O₂S₂
• CAS Number: 6505-99-3
• Molecular Weight: 341.45
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: S(CCN3CCOCC3)c1[nH]c2c(n1)N(C(=O)N(C2=S)C)C
• InChI: 1S/C13H19N5O2S2/c1-16-10-9(11(21)17(2)13(16)19)14-12(15-10)22-8-5-18-3-6-20-7-4-18/h3-8H2,1-2H3,(H,14,15)
• InChI key: XHNSOGDMSSHQFY-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

JA2131 is a cell penetrant, potent and selective poly(ADP-ribose) glycohydrolase (PARG) inhibitor that selectively kills cancer cells. JA2131 induces PARP1 hyper-PARylation and sensitizes cancer cells to radiation-induced DNA damage. JA2131 induces replication fork defects.

cell penetrant, potent and selective poly(ADP-ribose) glycohydrolase (PARG) inhibitor

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable