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Merck
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주요 문서

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PZ0203

Sigma-Aldrich

Sitaxentan sodium salt

≥98% (HPLC)

동의어(들):

N-(4-Chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-3-thiophenesulfonamide sodium salt, Sitaxsentan sodium salt, TBC-11251 sodium salt, Thelin

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About This Item

실험식(Hill 표기법):
C18H14ClN2NaO6S2
CAS Number:
210421-74-2
Molecular Weight:
476.89
UNSPSC 코드:
51111800
PubChem Substance ID:
329823772
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

양식

powder

색상

white to beige

solubility

H2O: 10 mg/mL (clear solution)

저장 온도

room temp

SMILES string

[Na+].Cc1cc2OCOc2cc1CC(=O)c3sccc3S(=O)(=O)[N-]c4onc(C)c4Cl

InChI

1S/C18H14ClN2O6S2.Na/c1-9-5-13-14(26-8-25-13)7-11(9)6-12(22)17-15(3-4-28-17)29(23,24)21-18-16(19)10(2)20-27-18;/h3-5,7H,6,8H2,1-2H3;/q-1;+1

InChI key

MDTNUYUCUYPIHE-UHFFFAOYSA-N

유전자 정보

human ... EDNRA(1909) , EDNRB(1910)

관련 카테고리

생화학적/생리학적 작용

Sitaxentan (Sitaxsentan) is a potent and selective endothelin ET(A) receptor antagonist once used in the treatment of pulmonary arterial hypertension (PAH), but removed from the market because of hepatotoxicity. It is over 6000-fold selective for the the ETA receptor subtype with an IC50 of 1 nM for ETA versus an IC50 of 9800 nM for ETB.
Sitaxentan is a potent and selective endothelin ET(A) receptor antagonist; antihypertensive.
Sitaxsentan prevents shunt mediated elevation of pulmonary vascular resistance (PVR). Sitaxsentan effectively inhibits basolateral Na+-taurocholate cotransporting polypeptide (NTCP), organic anion-transporting polypeptides (OATPs) and bile salt export pump (BSEP).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
082M4722V

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문서 라이브러리 방문

Sitaxsentan for the prevention of experimental shunt-induced pulmonary hypertension
Rondelet B, et al.
Pediatric Research, 61(3), 284-284 (2007)
Alex G Cuenca et al.
Innate immunity, 21(4), 386-391 (2014-08-12)
Neonates have increased susceptibility to infection, which leads to increased mortality. Whether or not this as a result of implicit deficits in neonatal innate immune function or recapitulation of innate immune effector cell populations following infection is unknown. Here, we
Daan van de Velde et al.
Biomedical chromatography : BMC, 34(3), e4787-e4787 (2019-12-26)
Endothelin receptor antagonists (ERAs) such as, ambrisentan, macitentan and sitaxentan are primarily used for the treatment of pulmonary arterial hypertension. Considering the rise in endothelin in pre-eclampsia, ERAs may also be useful in its treatment. To evaluate the pharmacokinetics of
Srinivas Akula et al.
Cells, 9(1) (2020-01-18)
Mast cells (MCs) are primarily resident hematopoietic tissue cells that are localized at external and internal surfaces of the body where they act in the first line of defense. MCs are found in all studied vertebrates and have also been
Shihab Shamma et al.
The Journal of the Acoustical Society of America, 145(2), 615-615 (2019-03-03)
Pitch is a fundamental attribute in auditory perception involved in source identification and segregation, music, and speech understanding. Pitch percepts are intimately related to harmonic resolvability of sound. When harmonics are well-resolved, the induced pitch is usually salient and precise
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