추천 제품
사용
sufficient for 100 colorimetric or fluorometric tests
검출 방법
colorimetric
fluorometric
관련 질환(들)
gastrointestinal diseases
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... GPT(2875)
mouse ... GPT(76282)
rat ... GPT(81670)
일반 설명
Alanine Aminotransferase (ALT), also known as serum glutamic-pyruvic transaminase (SGPT), is a pyridoxal-phosphate-dependent enzyme that catalyzes the reversible transfer of an amino group from alanine to α-ketoglutarate, generating pyruvate and glutamate. ALT is found primarily in liver and serum, but occurs in other tissues as well. Hepatocellular injury often results in an increase of serum ALT levels and serum ALT levels can be used as a marker for liver injury.
애플리케이션
ALT Activity Assay kit has been used to determine the activity of alanine aminotransferase (ALT) in serum samples.
특징 및 장점
Compatible with high-throughput handling systems.
적합성
Suitable for the measurement of alanine aminotransferase (ALT) activity in biological samples including tissue, cells and serum.
원리
The ALT Activity Assay Kit provides a simple and direct procedure for measuring ALT activity in a variety of biological samples.
ALT activity is determined by a coupled enzyme assay, which results in a colorimetric (570 nm)/ fluorometric (λex = 535/λem = 587 nm) product, proportional to the pyruvate generated. One unit of ALT is defined as the amount of enzyme that generates 1.0 μmole of pyruvate per minute at 37 °C.
ALT activity is determined by a coupled enzyme assay, which results in a colorimetric (570 nm)/ fluorometric (λex = 535/λem = 587 nm) product, proportional to the pyruvate generated. One unit of ALT is defined as the amount of enzyme that generates 1.0 μmole of pyruvate per minute at 37 °C.
관련 제품
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Aquatic Chronic 3 - Resp. Sens. 1 - Skin Sens. 1
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
Investigation of Therapeutic Effects of $\alpha$-Mangostin on Thioacetamide-Induced Cirrhosis in Rats
Nilbunga S.
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 98(9), S91-S97 (2015)
Brett Palaschak et al.
Molecular therapy. Methods & clinical development, 5, 142-152 (2017-05-10)
Multiple independent adeno-associated virus (AAV) gene therapy clinical trials for hemophilia B, utilizing different AAV serotypes, have reported a vector dose-dependent loss of circulating factor IX (FIX) protein associated with capsid-specific CD8
Nan Wu et al.
Laboratory investigation; a journal of technical methods and pathology, 97(7), 843-853 (2017-06-06)
The Hippo signaling pathway and the Notch signaling pathway are evolutionary conserved signaling cascades that have important roles in embryonic development of many organs. In murine liver, disruption of either pathway impairs intrahepatic bile duct development. Recent studies suggested that
Melissa F Brereton et al.
Nature communications, 7, 13496-13496 (2016-11-25)
Insulin secretion from pancreatic β-cells is impaired in all forms of diabetes. The resultant hyperglycaemia has deleterious effects on many tissues, including β-cells. Here we show that chronic hyperglycaemia impairs glucose metabolism and alters expression of metabolic genes in pancreatic
L Bočkor et al.
Gene therapy, 24(10), 649-660 (2017-08-15)
Adeno-associated virus (AAV) -mediated gene therapy is a promising strategy to treat liver-based monogenic diseases. However, two major obstacles limit its success: first, vector dilution in actively dividing cells, such as hepatocytes in neonates/children, due to the non-integrating nature of
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