R2533

RS-127445 hydrochloride

≥98% (HPLC), powder

• 동의어(들): 2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride
• 실험식(Hill 표기법): C₁₇H₁₆FN₃ · HCl
• CAS Number: 199864-86-3
• Molecular Weight: 317.79
• MDL number: MFCD11112196
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329824019
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to tan
• solubility: DMSO: ≥20 mg/mL
• 주관자: Roche
• 저장 온도: 2-8°C
• SMILES string: Cl.CC(C)c1cc(nc(N)n1)-c2ccc(F)c3ccccc23
• InChI: 1S/C17H16FN3.ClH/c1-10(2)15-9-16(21-17(19)20-15)13-7-8-14(18)12-6-4-3-5-11(12)13;/h3-10H,1-2H3,(H2,19,20,21);1H
• InChI key: MKJPYBJBPRFMHL-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist.

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.

특징 및 장점

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301,H315,H319,H335
• 예방조치 성명서: P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable