추천 제품
양식
powder or solid
Quality Level
분자량
5,000-25,000
색상
white to light yellow
응용 분야
cell analysis
저장 온도
−20°C
SMILES string
[N+H3][C@@H](Cc1[nH]cnc1)C(=O)[O-]
InChI
1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
InChI key
HNDVDQJCIGZPNO-YFKPBYRVSA-N
유사한 제품을 찾으십니까? 방문 제품 비교 안내
일반 설명
Poly-L-histidine is an amphoteric compound. The imidazole ring in its structure enables protonation−deprotonation.
애플리케이션
Poly-L-histidine has been used:
- as a polycation for the dispersion of multi-wall carbon nanotubes (MWCNTs)
- as a polyionic compound to investigate its ability to rupture extracellular enveloped virus membrane
- in screening its anti-prion activity in cell based and in vivo anti-prion assay
생화학적/생리학적 작용
Poly-L-histidine (Phis) copolymers are biocompatible, pH responsive and are less toxic. It exhibits endolysosomal escape funcationality. The copolymer of Phis with poly(ethylene glycol)−poly(d,l-lactide) (PEG-PLA) is effective in delivering doxorubicin. pH sensitive poly(l-histidine) copolymer micelles have application in delivering anticancer drugs in acidic microenvironment.
분석 메모
Molecular weight by MALLS.
기타 정보
For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
이미 열람한 고객
Hongbo Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(10), 1935-1944 (2012-07-12)
Many laboratories use recombinant UDP-glucuronosyltransferases (UGTs), expressed in baculovirus-infected insect cells, for drug glucuronidation studies. We have infected Sf9 insect cells with increasing amounts of recombinant baculovirus, encoding either UGT1A9 or UGT2B7, and measured both glucuronidation activity and immunodetectable UGT
Pablo R Dalmasso et al.
Biosensors & bioelectronics, 39(1), 76-81 (2012-07-17)
We report for the first time the development of a sensitive and selective glucose biosensor based on the self-assembling of multiwall carbon nanotubes (MWCNTs) dispersed in polyhistidine (Polyhis) and glucose oxidase (GOx) on glassy carbon electrodes (GCE). The supramolecular architecture
Shoichiro Asayama et al.
Bioconjugate chemistry, 23(7), 1437-1442 (2012-06-12)
Poly(L-histidine) (PLH) with dimethylimidazole groups has been synthesized as a pH-sensitive polypeptide to control the stability of its small interfering RNA (siRNA) polyion complexes for RNA interference (RNAi). The resulting methylated PLH (PLH-Me) was water-soluble despite deprotonation of the imidazole
Poly (l-histidine) based copolymers: effect of the chemically substituted l-histidine on the physio-chemical properties of the micelles and in vivo biodistribution
Zhang X, et al.
Colloids and Surfaces. B, Biointerfaces, 140(5), 176-184 (2016)
Yi-Fang Zeng et al.
Biomaterials, 33(36), 9239-9245 (2012-10-03)
Loading of viral vectors in synthetic polymers is a promising strategy for overcoming hurdles associated with viral gene delivery. For enhanced gene expression at a specific site, gene transfer by using hydrogels represents a versatile approach. In this study, adeno-associated
문서
Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.
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