G8761

(±)-Gossypol from cotton seeds

≥95% (HPLC), powder, PAF antagonist/inhibitor

• 동의어(들): (±)-2,2′-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene)
• 실험식(Hill 표기법): C₃₀H₃₀O₈
• CAS Number: 303-45-7
• Molecular Weight: 518.55
• MDL number: MFCD00017352
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24895349
• NACRES: NA.77

속성

• 제품명: (±)-Gossypol from cotton seeds, ≥95% (HPLC)
• Quality Level: 200
• 분석: ≥95% (HPLC)
• 저장 온도: 2-8°C
• SMILES string: O=C([H])C1=C(C(O)=C(C2=C(C)C=C(C(C(C)C)=C(O)C(O)=C3C([H])=O)C3=C2O)C(C)=C4)C4=C(C(C)C)C(O)=C1O
• InChI: 1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3
• InChI key: QBKSWRVVCFFDOT-UHFFFAOYSA-N
• 유전자 정보: human ... AKR1B1(231) , BAD(572) , BCL2(596) , LDHA(3939) , LDHB(3945) , MCL1(4170)

설명

일반 설명

Gossypol is considered as an antifertility agent. It is present in cottonseed as a yellowish pigment. This reactive sesquiterpene aldehyde is present in the family Malvaceae and has a molecular mass of 518.54.

애플리케이션

(±)-Gossypol from cotton seeds has been used:

• as a standard to quantify the gossypol content in the extracts of leaves and flower buds
• to study its antifertility effects on spermatogenesis in NMRI mice
• to analyse its impact on human spermatozoa
• to incorporate into the artificial diet for larval rearing

생화학적/생리학적 작용

Gossypol is a male antifertility agent and PAF antagonist/inhibitor. Gossypol is a poisonous pigment found in cottonseed and its name is derived from the botanical name of the cotton plant, Gossypium.. Gossypium is extracted from selected hybrid species between two Gossypium species, Gossypium hirsutum and Gossypium barbadens. As a PAF antagonist/inhibitor, Gossypium markedly inhibited the contractile responses of guinea pig lung parenchyma strips stimulated with leukotriene B₄, seukotriene D4, and PAF-acether.

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Danger
• 유해 및 위험 성명서: H302,H360F
• 예방조치 성명서: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 1B
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 개인 보호 장비: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges