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Merck
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주요 문서

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H4914

Sigma-Aldrich

Honokiol

≥98% (HPLC), powder

동의어(들):

5,3′-Diallyl-2,4′-dihydroxybiphenyl, NSC 293100

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About This Item

실험식(Hill 표기법):
C18H18O2
CAS Number:
35354-74-6
Molecular Weight:
266.33
MDL number:
MFCD00016674
UNSPSC 코드:
12352200
PubChem Substance ID:
24724501
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

양식

powder

저장 조건

desiccated

solubility

DMSO: 36 mg/mL

항생제 활성 스펙트럼

Gram-positive bacteria
neoplastics

동작 모드

DNA synthesis | interferes

저장 온도

2-8°C

SMILES string

Oc1ccc(cc1CC=C)-c2cc(CC=C)ccc2O

InChI

1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2

InChI key

FVYXIJYOAGAUQK-UHFFFAOYSA-N

유사한 제품을 찾으십니까? 방문 제품 비교 안내

일반 설명

Honokiol exhibits analgesic, antithrombotic, antispasmodic, antidepressant, antimicrobial and neuroprotective effects. It regulates gamma-aminobutyric acid (GABA) A receptors. Honokiol is associated with an increased risk of bleeding. It prevents platelet aggregation, protects myocardium from ischemic damage and inhibits ventricular arrhythmia.

애플리케이션

Honokiol has been used:
  • to study its effects on plasmid hSirt3102-399 deacetylation activity
  • as an antioxidant to study its cytoprotective role in human ovarian cancer cells (SKOV-3) and Chinese hamster ovary cells (CHOK1)
  • to explore its effects on oxidative stress and mitochondrial dysfunction via a sirt3-dependent manner
  • for intracerebroventricular (ICV) cannulation

생화학적/생리학적 작용

Honokiol is a natural biphenyl neolignan from magnolia extract. It is antiangiogenic, antitumor, and anxiolytic.

특징 및 장점

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

픽토그램

CorrosionEnvironment
GHS05,GHS09

신호어

Danger

유해 및 위험 성명서

H318,H411

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

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시험 성적서(COA)

Lot/Batch Number
066M4759V
105M4740V
074M4709V
123M4736V
092M4730V

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Atanas G Atanasov et al.
Biochimica et biophysica acta, 1830(10), 4813-4819 (2013-07-03)
Peroxisome proliferator-activated receptor gamma (PPARγ) agonists are clinically used to counteract hyperglycemia. However, so far experienced unwanted side effects, such as weight gain, promote the search for new PPARγ activators. We used a combination of in silico, in vitro, cell-based
The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABAA receptors
Alexeev M, et al.
Neuropharmacology, 62(8), 2507-2514 (2012)
Mitochondrial dynamics mediated by mitofusin 1 is required for POMC neuron glucose-sensing and insulin release control
Ramirez S, et al.
Cell Metabolism, 25(6), 1390-1399 (2017)
The role of phospholipase D in modulating the MTOR signaling pathway in polycystic kidney disease
Liu Y, et al.
PLoS ONE, 8(8), e73173-e73173 (2013)
Sirt3 ameliorates oxidative stress and mitochondrial dysfunction after intracerebral hemorrhage in diabetic rats
Zheng J, et al.
Frontiers in Neuroscience, 12, 526376-526376 (2018)
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관련 콘텐츠

Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of multicellular organisms, apoptosis is tightly regulated through two principal pathways by a number of regulatory and effector molecules.

Discover Bioactive Small Molecules for Cell Cycle Research

n proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during the synthesis (S) phase, which is followed by a second gap phase (G2) during which growth and preparation for cell division occurs. Together, these three stages comprise the interphase phase of the cell cycle. Interphase is followed by the mitotic (M) phase.

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