C4428

Cathepsin G from human leukocytes

lyophilized powder, ≥60 units/mg protein (Bradford)

• CAS Number: 107200-92-0
• EC 번호: 3.4.21.20 (BRENDA, IUBMB)
• MDL number: MFCD00130750
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human leucocytes
• Quality Level: 200
• 양식: lyophilized powder
• 특이 활성도: ≥60 units/mg protein (Bradford)
• 분자량: 23-30 kDa
• UniProt 수납 번호: P08311
• 배송 상태: dry ice
• 저장 온도: −20°C
• 유전자 정보: human ... CTSG(1511)

설명

일반 설명

Cathepsin G from human leukocytes is a neutral proteinase secreted by neutrophil granulocytes. It belongs to the family of serine proteases. Cathepsin G is a glycoprotein, which contains 1% carbohydrate. The gene is located on human chromosome 14q12.

애플리케이션

Cathepsin G from human leukocytes has been used to determine protease sensitivity. It has also been used for the stimulation and staining of dendritic cells and macrophage.

생화학적/생리학적 작용

Cathepsin G from human leukocytes degrades various proteins, such as elastin, collagen, fibrinogen and immunoglobin. It may be implicated in muscle catabolism. Cathepsin G is involved in the activation or inactivation of protein hormones and the inactivation of plasma proteinase inhibitors. It alters the cytoskeleton, enhances the permeability of vascular endothelial cells and the chemotaxis of inflammatory cells. Cathepsin G is associated with autoimmunity and cancer. It exhibits chymotrypsin and trypsin like activity. Cathepsin G modulates neutrophil effector functions.

Cathepsin G has pro-apoptotic activity and can activate caspases in vitro.

단위 정의

One unit will release one nanomole of p-nitroaniline per second from N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide at pH 7.5 at 37 °C.

물리적 형태

Lyophilized from 0.5 M pyridinium acetate, pH 5.3.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable