1.16887

Fractogel^® EMD TMAE (S)

• Synonyma: Biochromatography, Fractogel^® Ion exchangers, Ion exchanger for LC (Fractogel^® TSK/EMD), Fractogel^® EMD TMAE (S)
• UNSPSC Code: 41115711

Vlastnosti

• ligand: (Trimethylammoniumethyl)
• Quality Level: 400
• description: strong anion exchanger, suspension in 20% ethanol and 150 mM NaCl (20-40 µm)
• sterility: sterile (Caustic Stable)
• product line: Fractogel^®
• form: resin
• parameter: 8 bar max. pressure; 80 cm/hr flow rate
• matrix active group: methacrylate
• capacity: 100 mg binding capacity (BSA/mg of resin)
• transition temp: flash point 35 °C (calculated)
• density: 1.430 g/cm³ at 20 °C
• bulk density: 1000 kg/m³
• application(s): gene therapy; recombinant protein; vaccine development
• separation technique: anion exchange; strong anion exchange
• storage temp.: 2-30°C

Popis

General description

Stron anion exchange Fractogel^® resin with small particle size, featuring the tentacle technology with a trimethylammoniumethyl functional group, for purification of acidic and neutral proteins and peptides from multiple sources, DNA and virus removal, plasmid isolation, vaccine purification, and more

Features and Benefits

Fractogel^® EMD TMAE (S) (20-40 µm particle size) enables:

High protein loading conditions resulting in good selectivity and resolution with the tentacle technology

• Excellent binding to large viruses at increased loading
• Homogenous binding with high selectivity and purity
• Reduce operating costs and resin replacement with enduring durability - allowing for multiple cycles of column regeneration and sanitization
• Compatibility with 2.5 % (v/v) aqueous benzyl alcohol containing 150 mM NaCl storage solution

Packaging

• 1.16887.0100: Fractogel^® EMD TMAE (S) Resin 100ml
• 1.16887.0010: Fractogel^® EMD TMAE (S) Resin 10ml
• 1.16887.0500: Fractogel^® EMD TMAE (S) Resin 500ml
• 1.16887.5000: Fractogel^® EMD TMAE (S) Resin 5L

Plastic bottle

Analysis Note

Appearance: Milky turbid suspension, free from impurities (foreign particles)
Microscopic evaluation: Uniform spherical particles, no agglomerates, no fines
Extractable matter (water): ≤ 0.03 %
Ce content: ≤ 1 µg/g
Pressure drop(column: ID=1.6 cm, L=10 cm at 5 ml/min): ≤ 5.0 bar
Particle size (d10): 20 - 28 µm
Particle size (d50): 24 - 34 µm
Particle size (d90): 28 - 38 µm
Colony forming units (TAMC + TYMC): ≤ 100 CFU/ml
Endotoxins: ≤ 1.00 EU/ml
Protein binding capacity (bovine serum albumin): 80 - 120 mg/ml
Functional test (b:a): ≤ 0.1
Functional Test: Seperation of conalbumin and human serum albumin

Legal Information

FRACTOGEL is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• pictograms: GHS02
• signalword: Warning
• hcodes: H226
• pcodes: P210 - P233 - P240 - P241 - P242 - P243
• Hazard Classifications: Flam. Liq. 3
• Skladovací třída: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 95.0 °F
• flash_point_c: 35 °C