SBR00096

Lefamulin

≥98% (HPLC), powder

• Synonyme(s) : BC-3781
• Formule empirique (notation de Hill) : C₂₈H₄₅NO₅S
• Numéro CAS: 1061337-51-6
• Poids moléculaire : 507.73
• Code UNSPSC : 51101500

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria
• Mode d’action: protein synthesis | inhibits
• Conditions d'expédition: ambient
• Température de stockage: 2-8°C
• Chaîne SMILES: CC1CCC23CCC(=O)C2C1(C(CC(C(C3C)O)(C)C=C)OC(=O)CSC4CCC(CC4O)N)C
• InChI: 1S/C28H45NO5S/c1-6-26(4)14-22(34-23(32)15-35-21-8-7-18(29)13-20(21)31)27(5)16(2)9-11-28(17(3)25(26)33)12-10-19(30)24(27)28/h6,16-18,20-22,24-25,31,33H,1,7-15,29H2,2-5H3/t16-,17+,18-,20-,21-,22-,24+,25+,26-,27+,28+/m1/s1
• Clé InChI: KPVIXBKIJXZQJX-FCEONZPQSA-N

Description

Description générale

Lefamulin is an antibiotic which belongs to a class of coumpounds known as pleuromutilins. It is a semisynthetic derivative of the naturally occurring antibiotic pleuromutilin, and it is used for the treatment of bacterial infections.

Actions biochimiques/physiologiques

Lefamulin inhibits bacterial protein synthesis by binding to the 50S subunit of the bacterial ribosome. Specifically, it binds to the peptidyl transferase center of the ribosome and inhibits the transfer of amino acids to growing polypeptide chains, which leads to the inhibition of bacterial protein synthesis and bacterial death. Lefamulin is active against a wide range of Gram-positive bacteria, including Streptococcus pneumoniae, Staphylococcus aureus, and methicillin-resistant S. aureus (MRSA), as well as some atypical bacteria such as Legionella species. It has also been shown to have activity against some Gram-negative bacteria, including Haemophilus influenzae and Moraxella catarrhalis.

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Warning
• Mentions de danger: H371
• Conseils de prudence: P260 - P264 - P270 - P308 + P311 - P405 - P501
• Classification des risques: STOT SE 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable