233105

CL-82198

A selective inhibitor of MMP-13 (IC₅₀ = 10 µM).

• Synonyme(s) : CL-82198
• Formule empirique (notation de Hill) : C₁₇H₂₂N₂O₃ · xHCl
• Numéro CAS: 1188890-36-9
• Poids moléculaire : 302.37 (free base basis)
• Numéro MDL: MFCD09753278
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥97% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: light yellow
• Solubilité: water: 25 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: Cl.N3(CCOCC3)CCCCNC(=O)c1[o]c2c(c1)cccc2
• InChI: 1S/C17H22N2O3.ClH/c20-17(16-13-14-5-1-2-6-15(14)22-16)18-7-3-4-8-19-9-11-21-12-10-19;/h1-2,5-6,13H,3-4,7-12H2,(H,18,20);1H
• Clé InChI: PIOACXKZWXHBRB-UHFFFAOYSA-N

Description

Description générale

A selective inhibitor of MMP-13 (IC₅₀ = 10 µM) that does not appear to act by chelating Zn²⁺. Binds within the entire S1′ pocket of MMP-13, docking with the morpholine ring adjacent to the catalytic zinc atom. Does not inhibit MMP-1, MMP-9, and TACE.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
MMP-13

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 10 µM against MMP-13

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Chen, J.M., et al. 2000. J. Am. Chem. Soc.122, 9648.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable