Accéder au contenu
MilliporeSigma

PRMT6

protein arginine methyltransferase 6

Synonymes:
HRMT1L6
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(55170) Summary: The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]
  • Mouse(99890) protein arginine N-methyltransferase 6
  • Rat(295384) protein arginine methyltransferase 6
  • Thale Cress(821541) protein arginine N-methyltransferase 6
  • domestic cat(101093626) protein arginine methyltransferase 6
  • dog(490133) protein arginine methyltransferase 6
  • Zebrafish(448867) protein arginine methyltransferase 6
  • naked mole-rat(101715374) protein arginine methyltransferase 6
  • domestic guinea pig(100725259) protein arginine methyltransferase 6
  • cow(540228) protein arginine methyltransferase 6
  • sheep(101119859) protein arginine methyltransferase 6

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-PRMT6 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
Anti-PRMT6 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, rat
Application
ChIP
western blot
Anti-PRMT6 (N-term) antibody produced in rabbit, saturated ammonium sulfate (SAS) precipitated, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
immunohistochemistry

western blot
Anti-PRMT6 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
immunofluorescence
western blot
Anti-PRMT6 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
western blot

Proteins

Référence du produit
Description
Espèce(s)
PRMT6 human, recombinant, expressed in FreeStyle 293-F cells, ≥70% (SDS-PAGE),
Espèce(s)
human
PRMT6 active human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human PRMT6,
Espèce(s)
human
MISSION® esiRNA, targeting mouse Prmt6,
Espèce(s)
mouse