SRP2073

N-CoR human

recombinant, expressed in insect cells, ≥60% (SDS-PAGE)

• Synonym(s): KIAA1047, MGC104216, N-CoR, N-CoR1, TRAC1, hN-CoR
• UNSPSC Code: 12352202
• NACRES: NA.24

Properties

• biological source: human
• recombinant: expressed in insect cells
• assay: ≥60% (SDS-PAGE)
• form: frozen liquid
• mol wt: ~271 kDa
• packaging: pkg of 5 μg
• concentration: 700 μg/mL
• technique(s): deacetylase assay: suitable
• color: clear colorless
• NCBI accession no.: NM_006311
• UniProt accession no.: O75376
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... NCOR1(9611)

Description

Biochem/physiol Actions

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined

Physical form

Clear and colorless frozen liquid solution

Preparation Note

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable