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EMU039131

Sigma-Aldrich

MISSION® esiRNA

targeting mouse Plk1

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About This Item

UNSPSC Code:
41105324
NACRES:
NA.51
Pricing and availability is not currently available.

description

Powered by Eupheria Biotech

Quality Level

100

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

TGCTACAGCAGCTGACCAGTGTCAACGCCTCCAAGCCCTCGGAGCGCGGGCTGGTGCGGCAAGAGGAGGCTGAGGATCCTGCCTGCATCCCCATCTTCTGGGTCAGCAAGTGGGTGGACTATTCGGACAAGTATGGCCTTGGGTATCAGCTGTGTGACAACAGTGTGGGGGTGCTTTTTAATGACTCAACACGCCTGATTCTCTACAATGACGGGGACAGCCTGCAGTACATAGAGCGTGATGGCACGGAGTCCTATCTCACTGTGAGCTCCCATCCCAATTCCTTGATGAAGAAGATCACTCTCCTCAACTATTTCCGCAATTACATGAGTGAGCACCTGCTGAAGGCAGGACGCAACATCACACCCCGGGAAGGCGACGAGCTGGCCCGGCTGCCCTACCTACGAACGTGGTTCCGCACACGCAGCGCCATCATCCTGCACCTCAGCAACGGCACCGTGCAGATTAACTTCTTCCAGGACCACACCAAACTTATCCTGTGCCCCCT

Ensembl | mouse accession no.

ENSMUSG00000030867

NCBI accession no.

NM_011121

shipped in

ambient

storage temp.

−20°C

Gene Information

mouse ... PLK1(18817) , Plk1(18817)

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MISSION® esiRNA targeting mouse Plk1

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MISSION® esiRNA

MISSION® esiRNA targeting mouse Plg

EMU196041

MISSION® esiRNA

MISSION® esiRNA targeting mouse Pak1

EMU026031

MISSION® esiRNA

MISSION® esiRNA targeting mouse Pdk1

EMU059471

MISSION® esiRNA

esiRNA cDNA target sequence

TGCTACAGCAGCTGACCAGTGTCAACGCCTCCAAGCCCTCGGAGCGCGGGCTGGTGCGGCAAGAGGAGGCTGAGGATCCTGCCTGCATCCCCATCTTCTGGGTCAGCAAGTGGGTGGACTATTCGGACAAGTATGGCCTTGGGTATCAGCTGTGTGACAACAGTGTGGGGGTGCTTTTTAATGACTCAACACGCCTGATTCTCTACAATGACGGGGACAGCCTGCAGTACATAGAGCGTGATGGCACGGAGTCCTATCTCACTGTGAGCTCCCATCCCAATTCCTTGATGAAGAAGATCACTCTCCTCAACTATTTCCGCAATTACATGAGTGAGCACCTGCTGAAGGCAGGACGCAACATCACACCCCGGGAAGGCGACGAGCTGGCCCGGCTGCCCTACCTACGAACGTGGTTCCGCACACGCAGCGCCATCATCCTGCACCTCAGCAACGGCACCGTGCAGATTAACTTCTTCCAGGACCACACCAAACTTATCCTGTGCCCCCT

esiRNA cDNA target sequence

TACCACAGCAAAGAGCAGCAATGCGTGATCATGGCGGAGAACAGCAAGACTTCCTCCATCATCCGGATGAGAGACGTCATCTTATTCGAAAAGAGAGTGTATCTGTCAGAATGTAAGACCGGCATCGGCAACGGCTACAGAGGAACCATGTCCAGGACAAAGAGTGGTGTTGCCTGTCAAAAGTGGGGTGCCACGTTCCCCCACGTACCCAACTACTCTCCCAGTACACATCCCAATGAGGGACTAGAAGAGAACTACTGTAGGAACCCAGACAATGATGAACAAGGGCCTTGGTGCTACACTACAGATCCGGACAAGAGATATGACTACTGCAACATTCCTGAATGTGAAGAGGAATGCATGTACTGCAGTGGAGAAAAGTATGAGGGCAAAATCTCCAAGACCATGTCTGGACTTGACTGCCAGGCCTGGGATTCTCAGAGCCCACATGCTCATGGATACATCCCTGCCAAATTTCCAAGCAAGAACCTGAAGATGAATTATTGCCGCAACC

esiRNA cDNA target sequence

GGAGGTGGCCATTAAACAGATGAATCTTCAGCAGCAGCCGAAGAAAGAGCTGATTATTAATGAGATCCTGGTCATGAGGGAAAACAAAAACCCAAATATTGTCAACTACCTGGACAGTTACCTTGTGGGAGATGAGCTGTGGGTTGTTATGGAATACTTGGCTGGAGGCTCCTTGACAGATGTGGTGACAGAAACCTGTATGGATGAAGGCCAGATAGCAGCTGTGTGCCGAGAGTGTCTACAAGCTTTGGAGTTTCTACATTCAAACCAAGTCATTCACAGGGACATCAAGAGTGACAATATTCTGCTGGGAATGGATGGCTCTGTCAAGTTAACTGACTTTGGATTCTGTGCACAGATAACTCCAGAGCAGAGCAAAAGGAGCACCATGGTGGGAACTCCATATTGGATGGCACCTGAAGTTGTGACACGCAAGGCTTATGGACCCAAGGTTGA

esiRNA cDNA target sequence

TACGGGACAGATGCGGTTATCTACATTAAGGCTCTGTCTACAGAATCCGTCGAGAGACTCCCTGTGTACAATAAAGCCGCCTGGAAGCATTACAAAGCCAACCACGAGGCTGACGACTGGTGTGTGCCCAGCCGAGAGCCGAAAGACATGACCACATTCCGAAGCTCTTAAACGCACATGGGACGCCTGGCACATCCACATGTGGTTTCTGCTAAATTTGGAAGACATGTATTTGGAACCACACTGTTCCAAATATTTCACGTGTGATCTTCACAATTAGTGTTTGCTGAAGCTCCTAAAGGATCGGTTATGCCAACTGTATTCTGATGTGTTGGGTTAATTGGGCGTGGTTTTGAACACACATAATTTTGGTCAACTACCCTTGGTATGGTATGGGGTG

product line

MISSION®

product line

MISSION®

product line

MISSION®

product line

MISSION®

Gene Information

mouse ... PLK1(18817), Plk1(18817)

Gene Information

mouse ... PLG(18815), Plg(18815)

Gene Information

mouse ... PAK1(18479), Pak1(18479)

Gene Information

mouse ... PDK1(228026), Pdk1(228026)

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

NCBI accession no.

NM_011121

NCBI accession no.

NM_008877

NCBI accession no.

NM_011035

NCBI accession no.

NM_172665

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

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    Riet van der Meer et al.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 20(12), 3211-3221 (2014-04-29)
    To identify genes whose depletion is detrimental to Pim1-overexpressing prostate cancer cells and to validate this finding in vitro and in vivo. RNAi screening was used to identify genes whose depletion is detrimental to Pim1-overexpressing cells. Our finding was validated
    Valentina Zuco et al.
    Oncotarget, 6(11), 8736-8749 (2015-04-01)
    Intrinsic and acquired tumor drug resistance limits the therapeutic efficacy of camptothecins (CPTs). Downregulation of the mitotic kinase PLK1 was found associated with apoptosis induced by SN38 (CPT11 active metabolite). We investigated the role of PLK1 in the cell response
    Hui Tian et al.
    Molecular cancer research : MCR, 13(4), 784-794 (2015-01-13)
    Protein S-palmitoylation is a widespread and dynamic posttranslational modification that regulates protein-membrane interactions, protein-protein interactions, and protein stability. A large family of palmitoyl acyl transferases, termed the DHHC family due to the presence of a common catalytic motif, catalyzes S-palmitoylation;
    Sixin Jiang et al.
    Respiratory research, 16, 93-93 (2015-08-06)
    Polo-like kinase 1 (Plk1) is a serine/threonine protein kinase that has been implicated in the regulation of mitosis. In addition, the activation of mitogen-activated protein kinase (MAPK) is a key event in the early stage of the growth factor response.

    Global Trade Item Number

    SKUGTIN
    EMU039131-20UG4061831346879
    EMU039131-50UG4061828283040

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