추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
whole antiserum
항체 생산 유형
primary antibodies
클론
polyclonal
포함
15 mM sodium azide
종 반응성
chicken, rat, mouse
기술
western blot: 1:100 using rat or mouse brain tissue extract
UniProt 수납 번호
배송 상태
dry ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... MAPT(4137)
일반 설명
Tau (τ), also known as MAPT (microtubule associated protein tau) is encoded by the gene mapped on human chromosome 17q21.3. It is highly expressed in neurons but is most prominent in axons.
Tau (τ), also known as microtubule associated protein tau (MAPT) is encoded by the gene mapped on human chromosome 17q21.3. It is highly expressed in neurons but is most prominent in axons. Tau is a heat stable microtubule associated protein (MAP) with a molecular weight of 55- 65 kDa.
특이성
The antibody shows wide species reactivity. Anti-τ does not react with MAP1, MAP2 or tubulin. the antibody reacts with τ, one of the two major classes of heat stable microtubule-associated proteins (MAPs).
면역원
τ proteins from chicken embryo brain microtubules.
애플리케이션
Anti-τ (Tau) antibody produced in rabbit has been used as a primary antibody in western blotting.
생화학적/생리학적 작용
Removal of Tau (τ) results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). Tau helps in the assembly and maintenance of microtubule structure.
Variation in the MAPT gene encoding tau protein results in frontotemporal dementia. Tau protein acts as a substrate for many kinases.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
Yaqi Deng et al.
Genesis (New York, N.Y. : 2000), 52(4), 341-349 (2014-05-23)
Myelinogenesis is a complex process that involves substantial and dynamic changes in plasma membrane architecture and myelin interaction with axons. Highly ramified processes of oligodendrocytes in the central nervous system (CNS) make axonal contact and then extrapolate to wrap around
Dendritic Tau in Alzheimer?s Disease
Ittner A, et al.
Neuron, 99(1), 13-27 (2018)
C A Davies et al.
The American journal of pathology, 143(6), 1594-1605 (1993-12-01)
Several papers have described an 'amorphous' component of the amyloid in diffuse plaques and it has been suggested that this is 'preamyloid,' which is not organized into fibrils. Because most of the studies have been performed on autopsy tissue it
Beta-amyloid deposition and Alzheimer's type changes induced by Borrelia spirochetes
Miklossy J, et al.
Neurobiology of Aging, 27(2), 228-236 (2006)
Phosphorylation of microtubule-associated protein tau by Ca2+/calmodulin-dependent protein kinase II in its tubulin binding sites
Yamamoto H
Archives of Biochemistry and Biophysics, 408, 255-262 (2002)
문서
Alzheimer's disease (AD) is the most common cause of dementia in the elderly and is characterized by gradual loss of cognitive functions.
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