T4182

Tyrphostin AG 1478

≥98%

• 동의어(들): N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine
• 실험식(Hill 표기법): C₁₆H₁₄ClN₃O₂
• CAS Number: 175178-82-2
• Molecular Weight: 315.75
• MDL number: MFCD00270914
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24278735
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98%
• 양식: solid
• solubility: 0.1 M HCl: soluble <0.4 mg/mL; DMSO:methanol (1:1): soluble 10 mg/mL, clear, colorless; ethanol: soluble 10 mg/mL; methylene chloride: soluble 10 mg/mL; 0.1 M NaOH: insoluble; 2-hydroxypropyl-β-cyclodextrin: insoluble; H₂O: insoluble
• 저장 온도: 2-8°C
• SMILES string: COc1cc2ncnc(Nc3cccc(Cl)c3)c2cc1OC
• InChI: 1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20)
• InChI key: GFNNBHLJANVSQV-UHFFFAOYSA-N
• 유전자 정보: human ... EGFR(1956) ; mouse ... Egfr(13649)

설명

애플리케이션

Tyrphostin AG 1478 has been used as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor to study its effect on desmoid cell mobility in boyden chamber motility assays. It has also been used to inhibit phosphorylation of c-Met by exogenous transforming growth factor α in epidermoid carcinoma cell line A431.

생화학적/생리학적 작용

Selective inhibitor of epidermal growth factor receptor protein

Tyrphostin AG 1478 is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. It contributes to the development of hypomagnesemia and cardiac dysfunction in rats. Tyrphostin AG 1478 acts as a potential therapeutic agent for breast cancer.

특징 및 장점

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

제조 메모

Tyrphostin AG 1478 dissolves in DMSO:MeOH (1:1) at 10 mg/ml to yield a clear, colorless solution. It is also soluble in methylene chloride (10 mg/ml), ethanol (10 mg/ml) and 0.1 N HCl (less than 0.4 mg/ml). However, it is insoluble in water, 2-hydroxypropyl-β-cyclodextrin, and 0.1 N NaOH.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)