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Merck
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주요 문서

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SML0564

Sigma-Aldrich

PD153035 hydrochloride

≥98% (HPLC)

동의어(들):

4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline hydrochloride, AG 1517, PD 153035, SU 5271, ZM 252868

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About This Item

실험식(Hill 표기법):
C16H14BrN3O2 · HCl
CAS Number:
183322-45-4
Molecular Weight:
396.67
MDL number:
MFCD01074805
UNSPSC 코드:
51111800
PubChem Substance ID:
329825555
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

양식

powder

저장 조건

desiccated

색상

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

저장 온도

2-8°C

SMILES string

Cl.COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC

InChI

1S/C16H14BrN3O2.ClH/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11;/h3-9H,1-2H3,(H,18,19,20);1H

InChI key

ZJOKWAWPAPMNIM-UHFFFAOYSA-N

생화학적/생리학적 작용

PD153035 is an EGFR tyrosine kinase inhibitor.
PD153035 is apotent and selective ATP competitive inhibitor of the epidermal growth factor receptor tyrosine kinase EGFR.

특징 및 장점

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

픽토그램

Skull and crossbonesCorrosion
GHS06,GHS05

신호어

Danger

유해 및 위험 성명서

H301,H315,H318,H335

Hazard Classifications

Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
112M4622V

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Rainelli B Koumangoye et al.
Molecular cancer, 12(1), 167-167 (2013-12-21)
The expression of annexin A6 (AnxA6) in AnxA6-deficient non-invasive tumor cells has been shown to terminate epidermal growth factor receptor (EGFR) activation and downstream signaling. However, as a scaffolding protein, AnxA6 may stabilize activated cell-surface receptors to promote cellular processes
Amelia G Pérez et al.
Oncology reports, 44(4), 1649-1661 (2020-09-19)
Changes in protein levels in different components of the apical junctional complex occur in colorectal cancer (CRC). Claudin‑3 is one of the main constituents of tight junctions, and its overexpression can increase the paracellular flux of macromolecules, as well as
Naoya Hino et al.
Developmental cell, 53(6), 646-660 (2020-06-05)
During collective migration of epithelial cells, the migration direction is aligned over a tissue-scale expanse. Although the collective cell migration is known to be directed by mechanical forces transmitted via cell-cell junctions, it remains elusive how the intercellular force transmission
P Dhawan et al.
Oncogene, 30(29), 3234-3247 (2011-03-09)
Claudin-2 is a unique member of the claudin family of transmembrane proteins, as its expression is restricted to the leaky epithelium in vivo and correlates with epithelial leakiness in vitro. However, recent evidence suggests potential functions of claudin-2 that are
Benjamin Toh et al.
PLoS biology, 9(9), e1001162-e1001162 (2011-10-08)
In order to metastasize, cancer cells need to acquire a motile phenotype. Previously, development of this phenotype was thought to rely on the acquisition of selected, random mutations and thus would occur late in cancer progression. However, recent studies show
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