SRP0719

ALK2 (R206H), Active

PRECISIO^® Kinase, recombinant

• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• 재조합: expressed in baculovirus infected Sf9 cells
• 분석: 70-95% (SDS-PAGE)
• 양식: frozen liquid
• 특이 활성도: 5-7 nmol/min·mg (radiometric)
• 분자량: ~67 kDa
• 농도: 0.1 μg/μL
• 수납 번호(accession number): NM_001105
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... ALK2(90)

설명

애플리케이션

Useful for kinase assay.

생화학적/생리학적 작용

Recombinant human ALK2 (R206H) (147-end) was expressed by Baculovirus in Sf9 insect cells using an N-terminal GST tag. ALK2 belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins which encodes activin A type I receptor. ALK2 signals a particular transcriptional response in concert with activin type II receptors. Mutations in ALK2 are associated with fibrodysplasia ossificans progressiva (FOP) and the mutations are located in or adjacent to the GS regulatory region or active site of the kinase. The mutations in ALK2 were predicted by protein structure homology modeling to activate the ALK2 protein and enhance receptor signaling ⁽¹⁾. Dysregulated ALK2 kinase activity plays a role in the pathogenesis of FOP ⁽²⁾.

재구성

Formulated in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.

저장 및 안정성

Store in aliquots at -70°C. Avoid freeze/thaw cycles.

법적 정보

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable