SML3230

VU0360172 hydrochloride

≥98% (HPLC)

• 동의어(들): N-cyclobutyl-6-((3-fluorophenyl)ethynyl)nicotinamide hydrochloride
• 실험식(Hill 표기법): C₁₈H₁₅FN₂O · HCl
• CAS Number: 1309976-62-2
• Molecular Weight: 330.78
• MDL number: MFCD22683808
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• 저장 온도: −20°C
• SMILES string: FC1=CC=CC(C#CC2=NC=C(C=C2)C(NC3CCC3)=O)=C1.Cl
• InChI: 1S/C18H15FN2O.ClH/c19-15-4-1-3-13(11-15)7-9-16-10-8-14(12-20-16)18(22)21-17-5-2-6-17;/h1,3-4,8,10-12,17H,2,5-6H2,(H,21,22);1H
• InChI key: NBGAPTWZQXSEAA-UHFFFAOYSA-N

설명

일반 설명

VU0360172 is a potent (EC50 = 16.6 nM), systemically active positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 5 (mGlu5). It is the first orally active mGlu5 PAM to be efficacious in an in vivo preclinical antipsychotic model, producing a dose-dependent reversal of amphetamine-induced hyperlocomotion. It was also found to reduce spontaneous absence seizures in WAG/Rij rats and to inhibit pain. Reduced spontaneous spike and wave discharges without impacting motor behavior in a rat model of absence epilepsy have been observed.

생화학적/생리학적 작용

Potent, systemically active mGluR5 PAM

VU0360172 is a potent (EC50 = 16.6 nM), systemically active positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 5 (mGlu5). It is the first orally active mGlu5 PAM to be efficacious in an in vivo preclinical antipsychotic model, producing a dose-dependent reversal of amphetamine-induced hyperlocomotion. It was also found to reduce absence seizures in WAG/Rij rats and to inhibit pain.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable