SML4132

Tafamidis meglumine

≥98% (HPLC)

• 동의어(들): 2-(3,5-Dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid mono (1-deoxy-1-methylamino-D-glucitol), Fx 1006A, Fx-1006A, Fx1006A, PF 06291826, PF-06291826, PF06291826
• 실험식(Hill 표기법): C₂₁H₂₄Cl₂N₂O₈
• CAS Number: 951395-08-7
• Molecular Weight: 503.33
• UNSPSC 코드: 12352200

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: desiccated
• 색상: white to pink
• solubility: DMSO: 2 mg/mL, clear (Warmed)
• 저장 온도: 2-8°C

설명

생화학적/생리학적 작용

Transthyretin (TTR) tetramer stabilizer.
Tafamidis is a transthyretin (TTR) tetramer stabilizer that binds selectively and with negative cooperativity to the two normally unoccupied thyroxine-binding sites of the tetramer (Kd ~2 nM and ~200 nM), kinetically stabilizing the wild-type as well as the variant TTR complexes (V30M, F64S, Y69H, I84S, V122I, and L111M) and preventing their dissociation into fibril-forming monomers.

주의사항

Hygroscopic