SML3909

SGC-CK2-2

≥98% (HPLC)

• 동의어(들): 5-(Benzylamino)pyrimido[4,5-c]quinoline-8-carboxylic acid
• 실험식(Hill 표기법): C₁₉H₁₄N₄O₂
• CAS Number: 2825012-70-0
• Molecular Weight: 330.34
• MDL number: MFCD35067914
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C

설명

생화학적/생리학적 작용

Highly potent and selective casein kinase 2 (CK2, CKII) inhibitor that inhibits downstream AKT S129 phosphorylation in MDA-MB-231 cells

SGC-CK2-2 is a highly potent and selective casein kinase 2 (CK2, CKII) inhibitor (IC50 = 3 nM/CK2α and <1 nM/CK2α by enzyme assay; CK2α/CK2α′ IC50 = 920/200 nM by cellular NanoBRET; genomewide by DiscoverX scanMAX panel at 1 μM). SGC-CK2-2 effectively inhibits CK2 downstream signaling in MDA-MB-231 cells (AKT pS129 IC50 ~5 μM post 24h) without cytotoxicity (up to 10 μM & 48h).

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable