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Merck
모든 사진(1)

주요 문서

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SML1332

Sigma-Aldrich

NG25 trihydrochloride

≥98% (HPLC)

동의어(들):

N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-benzamide trihydrochloride, NG 25 trihydrochloride

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C29H30F3N5O2 · 3HCl
CAS Number:
1315355-93-1
Molecular Weight:
646.96
MDL number:
MFCD19443255
UNSPSC 코드:
12352200
PubChem Substance ID:
329825790
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

양식

powder

저장 조건

protect from light

색상

white to beige

solubility

H2O: 5 mg/mL, clear

저장 온도

2-8°C

SMILES string

CC1=CC=C(C(NC2=CC=C(CN3CCN(CC)CC3)C(C(F)(F)F)=C2)=O)C=C1OC4=C(C=CN5)C5=NC=C4

InChI

1S/C29H30F3N5O2/c1-3-36-12-14-37(15-13-36)18-21-6-7-22(17-24(21)29(30,31)32)35-28(38)20-5-4-19(2)26(16-20)39-25-9-11-34-27-23(25)8-10-33-27/h4-11,16-17H,3,12-15,18H2,1-2H3,(H,33,34)(H,35,38)

InChI key

SMPGEBOIKULBCT-UHFFFAOYSA-N

애플리케이션

NG25 trihydrochloride has been used as a transforming growth factor β (TGFβ)-activated kinase 1 inhibitor (TAK1) in human umbilical vein endothelial cells (HUVECs) and pulmonary artery smooth muscle cells.

생화학적/생리학적 작용

NG25 is multiple kinase inhibitor; potent dia; omjobotpr pf TAK1 and MAP4K2 kinases.
NG25 is potent multiple kinase inhibitor belonging to type II kinase inhibitors class that binds to kinase ATP binding pocket at not ready to catalyze conformation. NG25 is used as a potent dual inhibitor of TAK1 (TGFβ-Activated Kinase 1, MAP3K7) and MAP4K2 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2; GCK) kinases. NG25 inhibits the activation of IKKa/IKKb and prevents the secretion of type 1 IFNs by TLR2 and TLR9 agonist.

기타 정보

Light sensitive

픽토그램

Skull and crossbones
GHS06

신호어

Danger

유해 및 위험 성명서

H301,H413

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Chronic 4

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number
065M4703V

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