SML3516

EN106

≥98% (HPLC)

• 동의어(들): 2-Chloro-N-(2-cyanoethyl)-N-(2,3-dihydro-1,4-benzodioxin-6-yl)acetamide
• 실험식(Hill 표기법): C₁₃H₁₃ClN₂O₃
• CAS Number: 757192-67-9
• Molecular Weight: 280.71
• MDL number: MFCD06340076
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 2 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: O=C(CCl)N(C1=CC2=C(OCCO2)C=C1)CCC#N
• InChI key: GLDJSVHDOXCYPT-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

Cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B that binds to C186 of FEM1B

EN106 is a cell-permeable covalent recruiter of CUL2 E3 ligase FEM1B that binds to C186 of FEM1B. EN106 disrupts FEM1B interactions with the FNIP1 degron and inhibits CUL2FEM1B-dependent ubiquitylation without detectable off-target effects. A modified EN106 bifunctional analog (PROTAC) recruits FEM1B and induces targeted BRD4 and BCR-ABL/c-ABL degradation.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable