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Merck
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주요 문서

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SML3329

Sigma-Aldrich

Decursinol Angelate

≥98% (HPLC)

동의어(들):

(2Z)​-2-​Methyl-2-​butenoic acid (7S)​-​7,​8-​dihydro-​8,​8-​dimethyl-​2-​oxo-​2H,​6H-​benzo[1,​2-​b:5,​4-​b′]​dipyran-​7-​yl ester, Acutilobin

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C19H20O5
CAS Number:
130848-06-5
Molecular Weight:
328.36
MDL number:
MFCD06796687
UNSPSC 코드:
12352200
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

양식

powder

색상

white to beige

solubility

DMSO: 2 mg/mL, clear

저장 온도

-10 to -25°C

SMILES string

[o]1c2c(cc3c(c2)OC([C@H](C3)OC(=O)\C(=C/C)\C)(C)C)cc[c]1=O

InChI

1S/C19H20O5/c1-5-11(2)18(21)23-16-9-13-8-12-6-7-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/b11-5-/t16-/m0/s1

InChI key

AGABNGOXUSXQDD-XKGFZTIGSA-N

생화학적/생리학적 작용

Decursinol Angelate is a pyranocoumarin isolated from medical plant Angelica gigas that exhibits potent anti-inflammatory properties. Decursinol Angelate appears to suppress type 17 helper T (Th17) cell responses in dextran sodium sulfate-induced colitis model. Decursinol Angelate reduces the production of NF-κB and COX-2 induced proinflammatory cytokine levels on TPA induced mice ear edema.
Main anti-inflammatory component of Angelica gigas extract

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

표적 기관

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Sukkum Ngullie Chang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 132, 110699-110699 (2019-07-28)
Decursinol angelate (DA) is a pyranocoumarin purified from the roots of Angelica gigas. Here, we synthesized DA and determined its anti-inflammatory potential on TPA-induced mice ear inflammation. First, we evaluated the non-toxic behaviour of DA on HaCaT cells. Additionally, we
Bikash Thapa et al.
Biomolecules & therapeutics, 27(5), 466-473 (2019-03-29)
Angelica gigas has been used as a Korean traditional medicine for pain relief and gynecological health. Although the extracts are reported to have an anti-inflammatory property, the bioactive compounds of the herbal plant and the effect on T cell responses
Salman Ul Islam et al.
Molecules (Basel, Switzerland), 23(8) (2018-08-01)
Inflammation is considered the root cause of various inflammatory diseases, including cancers. Decursinol angelate (DA), a pyranocoumarin compound obtained from the roots of Angelica gigas, has been reported to exhibit potent anti-inflammatory effects. In this study, the anti-inflammatory effects of

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