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Merck
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주요 문서

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SML2385

Sigma-Aldrich

Andrastin A

≥95% (HPLC)

동의어(들):

(3β,5β,8α,9β,10α,13α)-3β-(acetyloxy)-4,4,8,12,16-pentamethyl-15,17,19-trioxoandrost-11-ene-14-carboxylic acid methyl ester

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C28H38O7
CAS Number:
174232-42-9
Molecular Weight:
486.60
MDL number:
MFCD28898503
UNSPSC 코드:
12352200

분석

≥95% (HPLC)

양식

powder

색상

white to beige

저장 온도

−20°C

SMILES string

O(C1C(C2[C@@]([C@@H]3C(C4([C@](C(=C3)C)(C(=O)C(C4=O)C)C)C(=O)OC)(CC2)C)(CC1)C=O)(C)C)C(=O)C

InChI

1S/C28H38O7/c1-15-13-19-25(6,28(23(33)34-8)22(32)16(2)21(31)26(15,28)7)11-9-18-24(4,5)20(35-17(3)30)10-12-27(18,19)14-29/h13-14,16,18-20H,9-12H2,1-8H3/t16?,18?,19-,20?,25?,26+,27+,28?/m0/s1

InChI key

GRBXNADBNJGZRK-BCMOVVIDSA-N

생화학적/생리학적 작용

Andrastin A is a meroterpenoid protein farnesyltransferase inhibitor with anticancer activity. It has been shown to inhibit the farnesyltransferase activity of the oncogenic Ras proteins and inhibit the efflux of anticancer drugs from multidrug-resistant cancer cells.
Farnesyltransferase inhibitor with anticancer activity; mycotoxin

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

Kristian Fog Nielsen et al.
Journal of agricultural and food chemistry, 53(8), 2908-2913 (2005-04-14)
This is the first finding of andrastins in blue cheese as well as any other sample type. Here, they were produced by the secondary starter culture Penicillium roqueforti. After purification by normal-phase chromatography followed by combined reverse-phase ion-exchange chromatography, the
Juan F Rojas-Aedo et al.
Frontiers in microbiology, 8, 813-813 (2017-05-23)
Penicillium roqueforti is a filamentous fungus involved in the ripening of several kinds of blue cheeses. In addition, this fungus produces several secondary metabolites, including the meroterpenoid compound andrastin A, a promising antitumoral compound. However, to date the genomic cluster
Mytre Koul et al.
Anti-cancer drugs, 28(1), 11-30 (2016-08-24)
Secondary metabolites from fungal endophytes have become an interesting, attractive, and alternative source for novel pharmaceuticals. Several novel compounds with diversified chemical structures have been isolated from endophytic fungi. The genus Penicillium has been exploited worldwide for its biosynthetic potential

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