SML2114
ZD7155 hydrochloride
≥97% (HPLC)
동의어(들):
5,7-Diethyl-3,4-dihydro-1-[[2’-(1H-tetrazol-5-yl)[1,1’-biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-one hydrochloride, ZD 7155
로그인조직 및 계약 가격 보기
모든 사진(1)
About This Item
실험식(Hill 표기법):
C26H26N6O · HCl
CAS Number:
Molecular Weight:
474.99
MDL number:
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
![4,9-Dibromo-2,7-bis(2-octyldodecyl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetrone](/deepweb/assets/sigmaaldrich/product/structures/100/693/87f6ccae-153b-4ba6-bd0a-653ba06ece22/640/87f6ccae-153b-4ba6-bd0a-653ba06ece22.png)
분석
≥97% (HPLC)
양식
powder
저장 조건
desiccated
색상
white to beige
solubility
H2O: 2 mg/mL, clear (warmed)
저장 온도
2-8°C
SMILES string
CCC1=C(C2=CC(CC)=N1)CCC(N2CC3=CC=C(C=C3)C4=C(C=CC=C4)C5=NN=NN5)=O.Cl
InChI
1S/C26H26N6O.ClH/c1-3-19-15-24-22(23(4-2)27-19)13-14-25(33)32(24)16-17-9-11-18(12-10-17)20-7-5-6-8-21(20)26-28-30-31-29-26;/h5-12,15H,3-4,13-14,16H2,1-2H3,(H,28,29,30,31);1H
InChI key
NAGGAAHTUXEGFG-UHFFFAOYSA-N
생화학적/생리학적 작용
Selective Angiotensin II AT1 antagonist
ZD7155 is a potent selective Angiotensin II AT1 antagonist. In one study ZD 7155 was found to be longer-acting and approximately ten times as potent as losartan in suppressing the angiotensin II-induced pressor response.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
가장 최신 버전 중 하나를 선택하세요:
I L Junggren et al.
The Journal of pharmacy and pharmacology, 48(8), 829-833 (1996-08-01)
Binding experiments show that ZD 7155 is a potent angiotensin II type 1 receptor antagonist. In this study this novel substance was studied in normotensive and hypertensive rats. The relative potency and duration of the antihypertensive effects of ZD 7155
Haitao Zhang et al.
Nature, 544(7650), 327-332 (2017-04-06)
The angiotensin II receptors AT
Signal Transduction and Targeted Therapy
Aung Than, Shaohai Xu, Ru Li, MelvinKhee-Shing Leow, Lei Sun and Peng Chen
Nature Chemical Biology, 2 (2017)
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