SML1929

Equisetin

(Fusarium equiseti), ≥97% (HPLC)

• 동의어(들): (3E,5S)-3-[[(1S,2R,4aS,6R,8aR)-1,6-dimethyl-2-[(E)-prop-1-enyl]-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl]-hydroxymethylidene]-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione
• 실험식(Hill 표기법): C₂₂H₃₁NO₄
• CAS Number: 57749-43-6
• Molecular Weight: 373.49
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Quality Level: 200
• 생물학적 소스: (Fusarium equiseti)
• 분석: ≥97% (HPLC)
• 양식: powder
• solubility: DMSO: soluble 1 mg/mL; chloroform: soluble 5 mg/mL
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: C[C@H]1C[C@]2([H])[C@@]([C@](C)(/C(O)=C3C([C@H](CO)N(C)C/3=O)=O)[C@H](/C=C/C)C=C2)([H])CC1
• InChI: 1S/C22H31NO4/c1-5-6-15-9-8-14-11-13(2)7-10-16(14)22(15,3)20(26)18-19(25)17(12-24)23(4)21(18)27/h5-6,8-9,13-17,24,27H,7,10-12H2,1-4H3/b6-5+/t13-,14-,15-,16-,17+,22-/m1/s1
• InChI key: SLOQQJFOWFUUMP-KNQICWOTSA-N

설명

생화학적/생리학적 작용

Equisetin is a tetramic acid analog derived from Fusarium equisti. Equisetin is mainly known for its antibiotic and cytotoxic activity and for its inhibitory effect on HIV-1 integrase. Inhibition of HIV integrase by Equisetin was reported with IC₅₀ values of 5-20 μM. Moreover, it was shown that Equisetin specifically inhibits the substrate anion carriers of the inner membrane of mitochondria and acts nonspecifically on protein membranes and protein hydrophobic domains. In addition, it was demonstrated that Equisetin causes phytotoxicity by causing root Necrosis and was also identified in a mycotoxin cocktail associated with cattle feeding problems.

Equisetin is a tetramic acid analog derived from Fusarium equisti.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable