SML1873

(2R,6R)-Hydroxynorketamine hydrochloride

≥98% (HPLC)

• 동의어(들): (2R,6R)-HNK hydrochloride; (2R,6R)-2-Amino-2-(2-chlorophenyl)-6-hydroxy-cyclohexanone hydrochloride
• 실험식(Hill 표기법): C₁₂H₁₄ClNO₂ · HCl
• CAS Number: 1430202-69-9
• Molecular Weight: 276.16
• MDL number: MFCD30182371
• UNSPSC 코드: 12352116
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 광학 활성: [α]/D -95 to -115°, c = 1 in H₂O
• 약물 제어: regulated under CDSA - not available from Sigma-Aldrich Canada
• 저장 조건: desiccated
• 색상: white to beige
• solubility: H₂O: 25 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: O=C1[C@@](C2=CC=CC=C2Cl)(N)CCC[C@H]1O.Cl
• InChI: 1S/C12H14ClNO2.ClH/c13-9-5-2-1-4-8(9)12(14)7-3-6-10(15)11(12)16;/h1-2,4-5,10,15H,3,6-7,14H2;1H/t10-,12-;/m1./s1
• InChI key: ZQJVHBJDLMIKJK-MHDYBILJSA-N

설명

생화학적/생리학적 작용

(2R,6R)-Hydroxynorketamine is a ketamine metabolite that has rapid antidepressant activity without ketamine-related side effects.

(2R,6R)-Hydroxynorketamine is a ketamine metabolite that has rapid antidepressant activity without ketamine-related side effects. The NMDAR antagonist (R,S)-ketamine must be metabolized to (2S,6S;2R,6R)-hydroxynorketamine (HNK) to have antidepressant effects. The (2R,6R)-HNK enantiomer appears to be the enantiomer most responsible for antidepressant effects in a mouse study and unlike (2S,6S)-HNK, (2R,6R)-HNK caused no significant changes in locomotion or coordination. (2R,6R)-HNK does not seem to have the same addiction potential as ketamine, since mice did not self-administer pharmacologically relevant doses of (2R,6R)-HNK under the same conditions where ketamine was readily self-administered. The (2R,6R)-HNK antidepressant appears to involve activation of AMPA glutamate receptors rather than inhibition of NMDA glutamate receptors.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H315,H319
• 예방조치 성명서: P264 - P270 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable