N7758

Naloxone hydrochloride dihydrate

≥98% (TLC and titration), powder

• 실험식(Hill 표기법): C₁₉H₂₁NO₄ · HCl · 2H₂O
• CAS Number: 51481-60-8
• Molecular Weight: 399.87
• Beilstein: 6260807
• MDL number: MFCD00150901
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278050
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥98% (TLC and titration)
• 양식: powder
• 광학 활성: [α]25/D −178.6°, c = 2.5 in H₂O(lit.)
• 색상: white to off-white
• solubility: ethanol: 3.3 mg/mL; H₂O: 50 mg/mL
• 저장 온도: 2-8°C
• SMILES string: O.O.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C
• InChI: 1S/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1
• InChI key: TXMZWEASFRBVKY-IOQDSZRYSA-N
• 유전자 정보: human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988) , OPRS1(10280)

설명

애플리케이션

Naloxone hydrochloride dihydrate has been used in:

• isotonic saline and injected subcutaneously into experimental rats to study its involvement with withdrawal syndrome in morphine-dependent rats
• as opioid receptor antagonist to examine the role of the endogenous opioid system in infantile amnesia for contextual fear
• as a reference neutral antagonist to define the maximum effect (Emax) of the system

생화학적/생리학적 작용

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

특징 및 장점

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

주의사항

Light sensitive.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves