SML0276
BD 1063 dihydrochloride
≥98% (HPLC)
동의어(들):
1-[2-(3,4-Dichlorophenyl)ethyl]-4-methylpiperazine dihydrochloride, BD1063 dihydrochloride
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C13H18Cl2N2 · 2HCl
CAS Number:
Molecular Weight:
346.12
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
양식
powder
저장 조건
desiccated
색상
white to beige
solubility
H2O: >15 mg/mL
저장 온도
room temp
SMILES string
Cl.Cl.CN1CCN(CC1)CCc2ccc(Cl)c(Cl)c2
InChI
1S/C13H18Cl2N2.2ClH/c1-16-6-8-17(9-7-16)5-4-11-2-3-12(14)13(15)10-11;;/h2-3,10H,4-9H2,1H3;2*1H
InChI key
NXFDBTLQOARIMH-UHFFFAOYSA-N
애플리케이션
BD 1063 dihydrochloride has been used as a sigma-1 receptor (S1R) antagonist:
- to study the in vitro and in vivo protective action of S1R against ferroptosis in hepatocellular carcinoma cells
- in a comparative evaluation of its anti-hyperalgesic action with that of the effects of N-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy) acetamide (NMIN) in a chronic constriction injury model (CCI)
- to study the contribution of sigma receptors inhibition to the neuroprotective effects of memantine against amyloid-beta (Aβ)-induced neurotoxicity in SH-SY5Y cells
생화학적/생리학적 작용
BD 1063 is a potent sigma(1) receptor antagonist.
BD 1063 is a potent sigma(1) receptor antagonist; approximately 50-fold selective for sigma-1 over sigma-2 and 100-fold or more selective over 9 other tested neurotransmitter receptors. BD 1063 has been shown to antagonize cocaine efffects.
기타 정보
air sensitive
신호어
Warning
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Mojtaba Keshavarz et al.
Advanced pharmaceutical bulletin, 10(3), 452-457 (2020-07-16)
Purpose: Memantine is an approved drug for the treatment of Alzheimer's disease (AD). Autophagy, lysosome dysfunction, and sigma receptors
Tao Bai et al.
Journal of cellular and molecular medicine, 23(11), 7349-7359 (2019-09-12)
Sigma-1 receptor (S1R) regulates reactive oxygen species (ROS) accumulation via nuclear factor erythroid 2-related factor 2 (NRF2), which plays a vital role in ferroptosis. Sorafenib is a strong inducer of ferroptosis but not of apoptosis. However, the mechanism of sorafenib-induced
Conor C Smith et al.
Molecular pharmacology, 86(4), 390-398 (2014-07-25)
Fast excitatory synaptic transmission that is contingent upon N-methyl d-aspartate receptor (NMDAR) function contributes to core information flow in the central nervous system and to the plasticity of neural circuits that underlie cognition. Hypoactivity of excitatory NMDAR-mediated neurotransmission is hypothesized
Michael A Wheeler et al.
Cell, 176(3), 581-596 (2019-01-22)
Genome-wide studies have identified genetic variants linked to neurologic diseases. Environmental factors also play important roles, but no methods are available for their comprehensive investigation. We developed an approach that combines genomic data, screens in a novel zebrafish model, computational
문서
Sigma receptors may constitute favorable targets for drug design in conditions such as psychiatric and movement disorders, amnesia, depression, cancer, inflammation and cocaine addiction.
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