SML0061

SAHA

≥98% (HPLC), powder, HDAC inhibitor

• 동의어(들): N-hydroxy-N′-phenyl-octanediamide, Suberoylanilide hydroxamic acid, Vorinostat
• 실험식(Hill 표기법): C₁₄H₂₀N₂O₃
• CAS Number: 149647-78-9
• Molecular Weight: 264.32
• MDL number: MFCD00945317
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825127
• NACRES: NA.77

속성

• 제품명: SAHA, ≥98% (HPLC)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to tan
• solubility: DMSO: ≥15 mg/mL
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: ONC(=O)CCCCCCC(=O)Nc1ccccc1
• InChI: 1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
• InChI key: WAEXFXRVDQXREF-UHFFFAOYSA-N
• 유전자 정보: human ... HDAC1(3065) , HDAC2(3066) , HDAC3(8841) , HDAC6(10013)

설명

애플리케이션

SAHA may be used to study gene regulation, transcription regulation and cell signaling.

생화학적/생리학적 작용

Potent, reversible pan-histone deacetylase (HDAC) inhibitor.

SAHA or Vorinostat facilitates the transcription of genes that result in apoptosis, differentiation and growth arrest. It has been observed to give beneficial results in lymphoma but not in solid tumors.

Vorinostat or suberoylanilide hydroxamic acid (SAHA) is a potent, reversible pan-histone deacetylase (HDAC) inhibitor. It inhibits both class I and class II HDACs, altering gene transcription and inducing cell cycle arrest and/or apoptosis in a wide variety of transformed cells.

특징 및 장점

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H341,H360
• 예방조치 성명서: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Muta. 2 - Repr. 1A
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable