추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 138 kDa
종 반응성
rat, mouse, human
농도
~1 mg/mL
기술
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... KCNT1(57582)
일반 설명
Anti-KCNT1 antibody detects endogenous levels of total KCNT1 protein.
The KCNT1 (potassium sodium-activated channel subfamily T member 1) gene is mapped to human chromosome 9q34.3. It is widely expressed in the brain, heart and dorsal root ganglia and well distributed in the nervous system.
면역원
The antiserum was produced against synthesized peptide derived from human KCNT1.
Immunogen Range: 1019-1068
Immunogen Range: 1019-1068
생화학적/생리학적 작용
Mutations in KCNT1 (potassium sodium-activated channel subfamily T member 1) is observed in different epileptic disorders including epileptic encephalopathy, nocturnal frontal lobe epilepsy and malignant migrating partial seizures in infancy. KCNT1 is associated with neural oscillation and general learning disability. It also controls pain sensation.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Missense mutations in the sodium-gated potassium channel gene KCNT1 cause severe autosomal dominant nocturnal frontal lobe epilepsy.
Heron SE
Nature Genetics, 44(11), 1188-1190 (2012)
Mutations in KCNT1 cause a spectrum of focal epilepsies.
M?ller RS
Epilepsia, 56(9) (2015)
Epilepsy-Related Slack Channel Mutants Lead to Channel Over-Activity by Two Different Mechanisms.
Tang QY
Cell Reports, 9314(1), 129-139 (2016)
Stimulation of Slack K(+) Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex.
Fleming MR
Cell Reports, 16(9), 2281-2288 (2016)
Characterization of two de novoKCNT1 mutations in children with malignant migrating partial seizures in infancy.
Rizzo F
Molecular and Cellular Neurosciences, 72, 54-63 (2016)
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