추천 제품
생물학적 소스
rabbit
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
분자량
antigen 31 kDa
종 반응성
human
농도
~1 mg/mL
기술
ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... TMEPA(56937)
일반 설명
Anti-TMEPA Antibody detects endogenous levels of total TMEPA protein.
The transmembrane prostate androgen-induced RNA (TMEPAI), also known as prostate transmembrane protein androgen induced 1 (PMEPA1) gene, spans 55-60 kb on human chromosome 20q13.31-q13.33. The encoded protein is mainly expressed in prostate gland and is regulated by androgen receptor (AR). TMEPAI is a type Ib transmembrane protein characterized with two PY motifs involved in binding HECT(homologous to the E6AP carboxyl terminus)-type E3 ubiquitin ligases.
면역원
The antiserum was produced against synthesized peptide derived from human TMEPA.
Immunogen Range: 101-150
Immunogen Range: 101-150
생화학적/생리학적 작용
Transmembrane prostate androgen-induced RNA (TMEPAI)/ prostate transmembrane protein androgen induced 1 (PMEPA1) plays a vital role in maintaining prostate homeostasis. It is also implicated in p53-mediated apoptosis and cell growth inhibition.
TMEPAI negatively regulate transforming growth factor- β (TGF-β) signaling in mammalian cells and Xenopus embryos. Upregulated expression of PMEPA1 stimulates cell migration and conserves the mesenchymal-like morphology of breast cancer cells. Deletion of the gene leads to prostate cancer.
TMEPAI negatively regulate transforming growth factor- β (TGF-β) signaling in mammalian cells and Xenopus embryos. Upregulated expression of PMEPA1 stimulates cell migration and conserves the mesenchymal-like morphology of breast cancer cells. Deletion of the gene leads to prostate cancer.
특징 및 장점
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
물리적 형태
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
면책조항
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
가장 최신 버전 중 하나를 선택하세요:
Wei Wu et al.
International journal of cancer, 143(9), 2213-2224 (2018-05-16)
TGF-β plays a central role in mediating epithelial-mesenchymal transition (EMT) by activating the Smad pathway. In addition, accumulating evidence suggests that TGF-β-induced EMT is NF-κB-dependent in various cancer types. However, it is largely unclear if NF-κB mediates TGF-β-induced EMT in
TMEPAI, a Transmembrane TGF-β-Inducible Protein, Sequesters Smad Proteins from Active Participation in TGF-β Signaling
Watanabe Y, et al.
Molecular Cell, 37(1), 123-134 (2010)
Transmembrane prostate androgen-induced protein 1 (PMEPA1) promotes the migration and maintains mesenchymal-like phenotype of breast cancer cells
Zou Y, et al.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 32(2), 158-162 (2016)
Shashwat Sharad et al.
Epigenetics, 9(6), 918-927 (2014-04-04)
The prostate transmembrane protein androgen induced 1 (PMEPA1) gene is highly expressed in prostate epithelial cells and is a direct transcriptional target for the androgen receptor (AR). AR protein levels are controlled by the AR-PMEPA1 negative feedback loop through NEDD4-E3
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