SAB4200693

Anti-CNPase antibody, Mouse monoclonal

clone 11-5B, purified from hybridoma cell culture

• 동의어(들): 2′,3′-cyclic-nucleotide 3′-phosphodiesterase, CNP, CNPase
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 200
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 11-5B, monoclonal
• 양식: buffered aqueous solution
• 분자량: antigen 46 kDa (CNP1); 48 kDa (CNP2)
• 종 반응성: pig (pig origin but not guinea pig), sheep, rat, bovine, rabbit, canine, human, mouse
• 농도: ~1 mg/mL
• 기술: immunoblotting: 5-10 μg/mL using whole rat brain extract
• 동형: IgG1
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... CNP(1267)

설명

일반 설명

Anti-CNPase antibody, Mouse monoclonal, (mouse IgG1 isotype) is derived from the 11-5B hybridoma produced by the fusion of mouse myeloma cells and splenocytes from RBF/Dn mouse immunized with human 2α,3α-cyclic nucleotide 3α-phosphodiesterase. CNPase (2α,3α-cyclic nucleotide 3α-phosphodiesterase), also known as CNP, is a membrane-anchored enzyme within the myelin sheath. CNPase is primarily a heterodimer of approximately 94 kDa. The heterodimer consists of a varied proportion of CNPase isoforms CNP1 (46 kDa) and CNP2 (48 kDa).

면역원

Human 2′,3′-cyclic nucleotide 3′-phosphodiesterase

애플리케이션

Anti-CNPase antibody, Mouse monoclonal has been used in immunoblotting, immunohistochemistry.

생화학적/생리학적 작용

CNPase (2α,3α-cyclic nucleotide 3α-phosphodiesterase), interacts with cytoskeletal proteins, cholesterol-rich cell membranes, nucleotides and various other proteins. Abnormalities in CNPase expression cause perturbations in myelin structure and are associated with neurological diseases such as schizophrenia and multiple sclerosis. It was shown that CNPase can bind Gag structural protein and prevent the assembly of HIV-1 particle, demonstrating the anti-viral activity of CNPase.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable