R0158

RepSox

≥98% (HPLC), solid, TGF-β RI kinase inhibitor

• 동의어(들): E-616452; 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine
• 실험식(Hill 표기법): C₁₇H₁₃N₅
• CAS Number: 446859-33-2
• Molecular Weight: 287.32
• MDL number: MFCD09037561
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329823975
• NACRES: NA.77

속성

• 제품명: RepSox, ≥98% (HPLC)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• solubility: DMSO: >20 mg/mL
• 저장 온도: 2-8°C
• SMILES string: Cc1cccc(n1)-c2n[nH]cc2-c3ccc4ncccc4n3
• InChI: 1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
• InChI key: LBPKYPYHDKKRFS-UHFFFAOYSA-N

설명

애플리케이션

RepSox has been used as an inhibitor of autophosphorylation of the transforming growth factor β type I receptor kinase (ALK5). It has also been used as a basal media component for culturing human Pluripotent stem cells.

생화학적/생리학적 작용

RepSox Inhibits TGF-beta receptor signaling.

RepSox Inhibits TGF-beta receptor signaling. Retroviral transduction of Sox2, Oct4, and Klf4 genes results in direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs).

RepSox inhibits osteoclast differentiation, resorption in bone tissues and ovariectomy (OVX)‐induced osteoporosis (OP) through repression of the SMAD family member 3 (Smad3) and c-Jun N-terminal kinase (JNK) pathway/ activator protein 1 (AP-1) pathways.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable