676380

Valproic Acid sodium salt

≥98% (HPLC), solid, HDAC1 inhibitor, Calbiochem^®

• 동의어(들): Valproic Acid, Sodium Salt, 2-Propylpentanoic Acid, Na
• 실험식(Hill 표기법): C₈H₁₅NaO₂
• CAS Number: 1069-66-5
• Molecular Weight: 166.19
• MDL number: MFCD00078604
• UNSPSC 코드: 12352106
• NACRES: NA.77

속성

• 제품명: Valproic Acid, Sodium Salt, A cell-permeable, short-chained fatty acid that inhibits histone deacetylase (IC₅₀ = 400 µM for HDAC1).
• Quality Level: 100
• 설명: Merck USA index - 14, 9913
• 분석: ≥98% (HPLC)
• 양식: solid
• 효능: 400 μM IC₅₀
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze; desiccated (hygroscopic)
• 색상: white
• solubility: water: 50 mg/mL
• 배송 상태: ambient
• 저장 온도: 2-8°C
• SMILES string: [Na+].[O-]C(=O)C(CCC)CCC
• InChI: 1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
• InChI key: AEQFSUDEHCCHBT-UHFFFAOYSA-M

설명

일반 설명

A cell-permeable, short-chained fatty acid that inhibits histone deacetylase activity (IC₅₀ = 400 µM for HDAC1). Induces differentiation and inhibits proliferation of cell lines derived from human malignant gliomas. At therapeutic levels (350 µM-1.04 mM), causes inositol depletion, inhibits both GSK-3α and -3β, activates the ERK pathway, and produces neurotropic effects. Has been used as an anti-epileptic agent. Also reported to stimulate peroxisome proliferator-activated receptor (PPAR) activity. Displays a potent teratogenic activity in humans and rodent models.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
HDAC1

Product does not compete with ATP.

Reversible: no

포장

Packaged under inert gas

경고

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

기타 정보

Gottlicher, M., et al. 2001. EMBO J.20, 6969.
Knupfer, M.M., et al. 2001. Anticancer Res.21, 347.
Phiel, C.J., et al. 2001. J. Biol. Chem.276, 36734.
Vaden, D.L., et al. 2001. J. Biol. Chem.276, 15466.
Yuan, P.X., et al. 2001. J. Biol. Chem.276, 31674.
Chen, G., et al. 1999. J. Neurochem.72, 1327.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• 픽토그램: GHS08,GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H361d
• 예방조치 성명서: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Hazard Classifications: Acute Tox. 4 Oral - Repr. 2
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable