N4288

Anti-NAV3 (C-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• 동의어(들): Anti-Neuron navigator 3, Anti-Pore membrane and/or filament interacting like protein 1 (POMFIL1), Anti-STEERIN3, Anti-human UNC-53 homolog (unc53H3)
• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 200
• 결합: unconjugated
• 항체 형태: affinity isolated antibody
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 양식: buffered aqueous solution
• 분자량: antigen ~280 kDa
• 종 반응성: human, mouse (predicted), rat (predicted)
• 포장: antibody small pack of 25 μL
• 향상된 검증: recombinant expression; Learn more about Antibody Enhanced Validation
• 농도: ~1 mg/mL
• 기술: western blot: 1-2 μg/mL using HEK-292T cells lysate expressing human NAV3 fusion protein
• UniProt 수납 번호: Q8IVL0
• 배송 상태: dry ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... NAV3(89795) ; mouse ... Nav3(260315) ; rat ... Nav3(314814)

설명

일반 설명

NAV3 belongs to the neuron navigator (NAV) family of proteins. NAV3 is expressed in adult heart, kidney, and brain.

Neuron navigator 3 (NAV3) is highly expressed in tumors. It possesses actin-binding domains and the gene encoding it is localized on chromosome 12q21.

애플리케이션

Anti-NAV3 (C-terminal) antibody has been used in immunoblotting, western blotting.

생화학적/생리학적 작용

NAV3 has been suggested to function as a novel tumor suppressor gene. Deletions and translocation affecting NAV3 have been shown to occur in patients with advanced mycosis fungoides or Sézary syndrome, the most common forms of primary cutaneous T-cell lymphoma (CTCL).

Neuron navigator 3 (NAV3) has been shown to control migration and invasion of epithelial cells. Once it is activated by growth factors, NAV3 occupies the ends of microtubules and stimulates their growth.

물리적 형태

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)