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Merck
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주요 문서

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L106

Sigma-Aldrich

Loxapine succinate salt

solid

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C18H18ClN3O · C4H6O4
CAS Number:
27833-64-3
Molecular Weight:
445.90
EC Number:
248-682-0
MDL number:
MFCD00069298
UNSPSC 코드:
12352200
PubChem Substance ID:
24277719
NACRES:
NA.77

양식

solid

Quality Level

100

색상

white

solubility

H2O: soluble

주관자

Watson

SMILES string

CN(CC1)CCN1C2=NC3=C(C=CC=C3)OC4=C2C=C(Cl)C=C4.OC(CCC(O)=O)=O

InChI

1S/C18H18ClN3O.C4H6O4/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18;5-3(6)1-2-4(7)8/h2-7,12H,8-11H2,1H3;1-2H2,(H,5,6)(H,7,8)

InChI key

YQZBAXDVDZTKEQ-UHFFFAOYSA-N

유전자 정보

human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR7(3363)

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생화학적/생리학적 작용

D2/D4 dopamine receptor antagonist; 5-HT2A/2B, 5-H7 serotonin receptor antagonist; dibenzoxazepine antipsychotic agent.

특징 및 장점

This compound was developed by Watson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
BCCH0822
BCCG7141
BCBT9175
BCBP7940V
BCBN6090V

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특정 버전이 필요한 경우 로트 번호나 배치 번호로 특정 인증서를 찾을 수 있습니다.

COA 검색

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Clozapine

Sigma-Aldrich

C6305

Clozapine

Amitriptyline hydrochloride ≥98% (TLC), powder

Sigma-Aldrich

A8404

Amitriptyline hydrochloride

Andrea Reed et al.
Drug metabolism letters, 6(1), 26-32 (2012-02-04)
The antipsychotic drugs risperidone, paliperidone, olanzapine, quetiapine, aripiprazole, clozapine, haloperidol, and chlorpromazine have been reported to have various degrees of interaction (substrate or inhibitor) with the multidrug resistance transporter, P-glycoprotein (P-gp). An interaction of the antipsychotic drug loxapine with P-gp
H O Kalkman et al.
British journal of pharmacology, 124(7), 1550-1556 (1998-09-02)
1. The mechanism underlying the anticataleptic properties of the atypical neuroleptic agent, clozapine, has been investigated in the rat. 2.The close structural analogues of clozapine, loxapine (0.1 mg kg(-1) s.c.) and iso-clozapine (1 and 3 mg kg(-1) s.c.) induced catalepsy
Tamara Pringsheim et al.
Canadian journal of psychiatry. Revue canadienne de psychiatrie, 56(10), 630-634 (2011-10-22)
To describe the frequency and trends in the use of antipsychotics for adults with schizophrenia in Canada from 2005 to 2009. Analyses were performed on IMS Brogan's Canadian Disease and Therapeutic Index (CDTI). The CDTI is a national physician panel
D Fiorella et al.
Psychopharmacology, 121(3), 347-356 (1995-10-01)
Investigations conducted over the past 3 decades have demonstrated that serotonergic receptors, specifically the 5-HT2A and 5-HT2C subtypes, play an important role in the behavioral effects of hallucinogenic compounds. The present study was designed to determine the respective significance of
Joseph Kwentus et al.
Bipolar disorders, 14(1), 31-40 (2012-02-15)
The present study evaluated inhaled loxapine for the acute treatment of agitation in patients with bipolar I disorder. A Phase 3, randomized, double blind, placebo-controlled, parallel group inpatient study was performed at 17 psychiatric research facilities. Agitated patients (N=314) with
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