추천 제품
생물학적 소스
chicken
Quality Level
결합
unconjugated
항체 형태
affinity isolated antibody
항체 생산 유형
primary antibodies
클론
polyclonal
양식
buffered aqueous solution
종 반응성
human
제조업체/상표
Genway 15-288-21229
기술
western blot: suitable
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
타겟 번역 후 변형
unmodified
유전자 정보
human ... CLIF(56938)
애플리케이션
Anti-CLIF antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
생화학적/생리학적 작용
The CLIF gene encodes a member of the basic helix-loop-helix PER-ARNT-SIM family of transcription factors and is located on chromosome12. It helps in controlling diverse physiological processes including circadian rhythm. CLIF is expressed in endothelial cells and neurons in the brain, including the suprachiasmatic nucleus and the center of the circadian clock. In endothelial cells, it forms a heterodimer with CLOCK and up-regulates the PAI-1 gene through E-box sites. CLIF helps in regulating the circadian oscillation of PAI-1 gene expression in endothelial cells. Its expression is increased in colorectal cancer and is related to tumor invasiveness and aggressiveness.
물리적 형태
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
가장 최신 버전 중 하나를 선택하세요:
Gianluigi Mazzoccoli et al.
Journal of cancer research and clinical oncology, 138(3), 501-511 (2011-12-27)
Cathepsin and plasmin may favor cancer cell invasion degrading extracellular matrix. Plasmin formation from plasminogen is regulated by plasminogen activator inhibitor type-1 (PAI-1). ARNTL2 activates the promoters of the PAI-1 gene, officially called SERPINE1, driving the circadian variation in circulating
K Maemura et al.
The Journal of biological chemistry, 275(47), 36847-36851 (2000-10-06)
The onset of myocardial infarction occurs frequently in the early morning, and it may partly result from circadian variation of fibrinolytic activity. Plasminogen activator inhibitor-1 activity shows a circadian oscillation and may account for the morning onset of myocardial infarction.
John A Schoenhard et al.
American journal of physiology. Cell physiology, 283(1), C103-C114 (2002-06-11)
The BMAL2 gene encodes a member of the basic helix-loop-helix PER-ARNT-SIM family of transcription factors, which control diverse physiological processes including circadian rhythms. We identified four novel human BMAL2 transcripts that differ by alternative splicing within their NH2-terminal regions. Divergent
M Ikeda et al.
Biochemical and biophysical research communications, 275(2), 493-502 (2000-08-31)
We isolated a human cDNA encoding a novel member of the bHLH-PAS transcription factor superfamily, BMAL2, which is highly similar to, but distinct from, BMAL1. The composite cDNA covered a 1720-bp sequence consisting of a putative 1653-bp open reading frame
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