G2911
GF 109203X
synthetic, ≥90% (HPLC)
동의어(들):
3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimide, 3-[1-[3-(Dimethylamino)propyl]1H-indol-3-yl]-4-(1Hindol-3-yl)1H-pyrrole-2,5dione, Bisindolylmaleimide I
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C25H24N4O2
CAS Number:
Molecular Weight:
412.48
MDL number:
UNSPSC 코드:
12352202
PubChem Substance ID:
NACRES:
NA.77
추천 제품
생물학적 소스
synthetic
Quality Level
분석
≥90% (HPLC)
solubility
DMSO: soluble (~1 mg/ml)
저장 온도
2-8°C
SMILES string
CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15
InChI
1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
InChI key
QMGUOJYZJKLOLH-UHFFFAOYSA-N
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애플리케이션
GF 109203X has been used as a protein kinase C inhibitor in HUVECs (human umbilical vein endothelial cells), angiotensinogen gene knockout (AGT KO) mice, and in granulosa cell cultures of female rats.
생화학적/생리학적 작용
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca2+ resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca2+ resorption elicited by a number of agents, but GF109203X counteracted that enhancement.
A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). In certain cells, inhibition of PKC leads to an increase in autophagy. For PKC inhibition, typically used at a concentration of 0.1-10 μM.
수량
For PKC inhibition, typically used at a concentration of 0.1-10 μM.
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Carc. 1B
보충제 위험성
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
이미 열람한 고객
Follicle-stimulating hormone (FSH) stimulates phosphorylation and activation of protein kinase B (PKB/Akt) and serum and glucocorticoid-induced kinase (Sgk): evidence for A kinase-independent signaling by FSH in granulosa cells.
Gonzalez-Robayna IJ, et al.
Molecular Endocrinology, 14(8), 1283-1300 (2000)
Kristin Klarström Engström et al.
Scientific reports, 9(1), 2296-2296 (2019-02-21)
To prevent the onset of urosepsis and reduce mortality, a better understanding of how uropathogenic Escherichia coli (UPEC) manages to infiltrate the bloodstream through the kidneys is needed. The present study elucidates if human renal interstitial fibroblasts are part of
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Environmental toxicology and pharmacology, 48, 197-202 (2016-11-07)
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Src is required for mechanical stretch-induced cardiomyocyte hypertrophy through angiotensin II type 1 receptor-dependent beta-arrestin2 pathways.
Wang S, et al.
PloS one, 9(4), e92926-e92926 (2014)
Jingzhen Yuan et al.
Frontiers in physiology, 8, 1014-1014 (2017-12-23)
Nuclear factor-kappa B (NF-κB) activation is a key early signal regulating inflammatory and cell death responses in acute pancreatitis. Our previous
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