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Merck
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주요 문서

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E5406

Sigma-Aldrich

Ethopropazine hydrochloride

≥98% (HPLC), powder

동의어(들):

10-(2-Diethylaminopropyl)phenothiazine, 10-[2-(Diethylamino)propyl]phenothiazine hydrochloride, Dibutil hydrochloride, Parkin

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About This Item

실험식(Hill 표기법):
C19H24N2S · HCl
CAS Number:
1094-08-2
Molecular Weight:
348.93
EC Number:
214-134-4
MDL number:
MFCD00012653
UNSPSC 코드:
12352200
PubChem Substance ID:
329799070
NACRES:
NA.77

Quality Level

100

분석

≥98% (HPLC)

양식

powder

저장 조건

desiccated

색상

white

solubility

DMSO: >5 mg/mL at ~60 °C, clear

저장 온도

2-8°C

SMILES string

Cl[H].CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13

InChI

1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H

InChI key

VXPCQISYVPFYRK-UHFFFAOYSA-N

유전자 정보

human ... CHRM1(1128)

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일반 설명

Ethopropazine hydrochloride possess anticholinergic, antihistamine and antiadrenergic properties.

생화학적/생리학적 작용

Ethoproprazine hydrochloride is an inhibitor of butyrylcholinesterase; antiparkinsonian
Ethoproprazine hydrochloride is an inhibitor of butyrylcholinesterase; antiparkinsonian. It reduces extrapyramidal motor effects, characteristic of Parkinson′s disease; also alleviates thermal hyperalgesia in rats.

특징 및 장점

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H302

예방조치 성명서

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

dust mask type N95 (US), Eyeshields, Gloves

가장 최신 버전 중 하나를 선택하세요:

시험 성적서(COA)

Lot/Batch Number
096M4753V
055M4711V
012M4707V
031M4744V
098K47142

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COA 검색

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문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Derek P Narendra et al.
PLoS biology, 8(1), e1000298-e1000298 (2010-02-04)
Loss-of-function mutations in PINK1 and Parkin cause parkinsonism in humans and mitochondrial dysfunction in model organisms. Parkin is selectively recruited from the cytosol to damaged mitochondria to trigger their autophagy. How Parkin recognizes damaged mitochondria, however, is unknown. Here, we
Transition Metal Complexes of Ethopropazine: Synthesis and Characterization
Debbeti V, et al.
American Journal of Chemistry, 2(6), 294-298 (2012)
Katherine C M Chew et al.
PloS one, 6(5), e19720-e19720 (2011-06-01)
Mutations in the parkin gene, which encodes a ubiquitin ligase (E3), are a major cause of autosomal recessive parkinsonism. Although parkin-mediated ubiquitination was initially linked to protein degradation, accumulating evidence suggests that the enzyme is capable of catalyzing multiple forms
Min Fu et al.
Molecular biology of the cell, 24(8), 1153-1162 (2013-02-22)
Glycoprotein 78 (Gp78) is a critical E3 ubiquitin ligase in endoplasmic reticulum-associated degradation. Overexpression of Flag-tagged Gp78 (Flag-gp78), but not Flag-gp78 mutated in its RING-finger domain (Flag-RINGmut) with deficient ubiquitin ligase activity, induces mitochondrial fragmentation and ubiquitination and proteasome-dependent degradation
Louis de Léséleuc et al.
PLoS neglected tropical diseases, 7(1), e2015-e2015 (2013-01-26)
Leprosy is a persistent infectious disease caused by Mycobacterium leprae that still affects over 200,000 new patients annually. The host genetic background is an important risk factor for leprosy susceptibility and the PARK2 gene is a replicated leprosy susceptibility candidate
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문서

Acetylcholine Synthesis and Metabolism

Acetylcholine is synthesized from acetyl coenzyme A and choline by the enzyme choline acetyltransferase. In addition to its synthesis in the liver, choline employed in acetylcholine production is derived from dietary sources.

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