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Merck
모든 사진(1)

주요 문서

D2697

Sigma-Aldrich

Dihydralazine sulfate

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About This Item

실험식(Hill 표기법):
C8H12N6O4S
CAS Number:
Molecular Weight:
288.28
EC Number:
MDL number:
UNSPSC 코드:
51102829
PubChem Substance ID:
NACRES:
NA.85

양식

powder

Quality Level

solubility

DMSO: 1 mg/mL

동작 모드

cell membrane | interferes

저장 온도

−20°C

SMILES string

OS(O)(=O)=O.NNC1=NNC(=N/N)\c2ccccc12

InChI

1S/C8H10N6.H2O4S/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7;1-5(2,3)4/h1-4H,9-10H2,(H,11,13)(H,12,14);(H2,1,2,3,4)

InChI key

BWHAMWGGORIDBK-UHFFFAOYSA-N

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생화학적/생리학적 작용

Dihydralazine sulfate is a vasodilator and an antihypertensive agent. It relaxes arterial smooth muscle by inhibiting the accumulation of intracellular free calcium. By relaxing vascular smooth muscle, vasodilators act to decrease peripheral resistance.

기타 정보

Keep container tightly closed in a dry and well-ventilated place.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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시험 성적서(COA)

Lot/Batch Number

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문서 라이브러리 방문

D I Barry et al.
Stroke, 15(1), 102-108 (1984-01-01)
The cerebrovascular effects of graded, controlled dihydralazine-induced hypotension were studied in rats with renal hypertension (RHR) and spontaneous hypertension (SHR). Repeated measurements of cerebral blood flow (CBF) were made using the intraarterial 133Xenon injection technique in anaesthetised normocapnic animals. Dihydralazine
Helen J Knowles et al.
Circulation research, 95(2), 162-169 (2004-06-12)
The vasodilator hydralazine, used clinically in cardiovascular therapy, relaxes arterial smooth muscle by inhibiting accumulation of intracellular free Ca2+ via an unidentified primary target. Collagen prolyl hydroxylase is a known target of hydralazine. We therefore investigated whether inhibition of other
Anna Gumieniczek et al.
Chromatographia, 81(8), 1147-1162 (2018-09-18)
Dihydralazine and hydrochlorothiazide were stored at high temperature and humidity, under UV/Vis light and different pH, as individual drugs and the mixture. Then, a sensitive and selective HPLC-UV method was developed for simultaneous determination of dihydralazine and hydrochlorothiazide in presence

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