B6060

BVT.948

≥98% (HPLC), solid

• 동의어(들): 4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione
• 실험식(Hill 표기법): C₁₄H₁₁NO₃
• CAS Number: 39674-97-0
• Molecular Weight: 241.24
• MDL number: MFCD00616487
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24724422
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 저장 조건: desiccated; protect from light; under inert gas
• 색상: red
• solubility: DMSO: 18 mg/mL; H₂O: insoluble
• 저장 온도: −20°C
• SMILES string: CC1(C)C(=O)N=C2c3ccccc3C(=O)C(O)=C12
• InChI: 1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3
• InChI key: BAQXWJQSUXZVIP-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.

특징 및 장점

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H317
• 예방조치 성명서: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves