S6508

Sodium orthovanadate

≥90% (titration)

• 동의어(들): Trisodium vanadate
• Linear Formula: Na₃VO₄
• CAS Number: 13721-39-6
• Molecular Weight: 183.91
• EC Number: 237-287-9
• MDL number: MFCD00003511
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24899708
• NACRES: NA.77

속성

• 생물학적 소스: synthetic (organic)
• Quality Level: 200
• 분석: ≥90% (titration)
• 양식: crystalline powder
• 반응 적합성: reagent type: catalyst; core: vanadium
• 색상: white to off-white
• mp: 850-866 °C (lit.)
• solubility: H₂O: soluble
• SMILES string: [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O
• InChI: 1S/3Na.4O.V/q3*+1;;3*-1;
• InChI key: IHIXIJGXTJIKRB-UHFFFAOYSA-N

설명

애플리케이션

Sodium orthovandate was used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase.²⁶ It was one of the reagents used in the development of Matrix ChIP that utilizes surface-immobilized antibodies.²⁷

생화학적/생리학적 작용

Inhibits ATPase, alkaline phosphatase and tyrosine phosphatase. Decavanadate, which is formed at acidic pH, inhibits inositol 1,4,5-trisphosphate (IP₃)-induced Ca²⁺ release from endocrine cells and blocks IP₃ binding to its receptor in brain tissue.

Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice.²⁴ In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.²⁵

특징 및 장점

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

기타 정보

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302 + H312 + H332,H315,H319
• 예방조치 성명서: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves